Structural Identification of Chemical Constituents from Scutellaria baicalensis by HPLC-ESI-MS/MS and NMR Spectroscopy
文献类型：期刊论文
| 作者 | Lin, Wenhui1; Liu, Shuang2,3; Wu, Bin3 |
| 刊名 | ASIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2013-07 |
| 卷号 | 25期号:7页码:3799-3805 |
| 关键词 | Scutellaria bacialensis Structural elucidation Chemical constituents HPLC-MS/MS NMR |
| ISSN号 | 0970-7077 |
| DOI | 10.14233/ajchem.2013.13788 |
| 文献子类 | Article |
| 英文摘要 | Scutellaride Radix, the dried roots of Scutellaria baicalensis Georgi, which is one of the famous herb widely used in. the treatment of pyrexia, jaundice and hypertension. To directly identify the compounds of the,extract the S. baicalensis was performed using HPLC-ESI-MS/MS. Chromatographic (analytical and preparative HPLC), chemical (hydrolysis) and spectroscopic (UV, H-1 and C-13 NMR, MS) techniques were applied for separation, isolation, purification and identification of new compounds. A systematic phytochemical investigantion of S. baicalensis led to the isolation of 7 new and 40 known chemical, constituents. By HPLC-ESI-MS/MS, and NMR spectral analyses, the new compounds were identified 7-hydrox-3,5,8-trimethoxy-3',4'-methylenedioxy flavone-7-O-beta-glucopyranoside (1), 7-hydroxy-5,6,8-trimethoxy,-3',4'-methylenedioxy flavone-7-O-beta-glucopyranoside (2), patuletin-7-beta-glucuronide (1), pinobankasin-6-C-glucopyranosyl-8-C-arabinopyranoside (4), chrysin-3-C-alpha-arabinopyranosyl-8-C-beta-glucopyranoside (11), 6-sulfooxy-chrysin-7-glucosicle (12) and 5-hydoxy-6,74'-trimethoxy-flavanone 5-sulfate (24). |
| WOS关键词 | FLAVONOID CONSTITUENTS ; C-GLYCOSIDES ; C-13 NMR ; GEORGI ; METABOLITES ; ROOTS |
| 资助项目 | National Science and Technology Major Project Key New Drug Creation and Manufacturing Program, China[2009ZX09301-001] ; National Science and Technology Major Project Key New Drug Creation and Manufacturing Program, China[2009ZX09308-005] ; National Natural Science Foundation of China[81030065] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000317246300056 |
| 出版者 | ASIAN JOURNAL OF CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277577]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Bin |
| 作者单位 | 1.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 2.Haerbin Univ Commerce, Haerbin 150076, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Wenhui,Liu, Shuang,Wu, Bin. Structural Identification of Chemical Constituents from Scutellaria baicalensis by HPLC-ESI-MS/MS and NMR Spectroscopy[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(7):3799-3805. |
| APA | Lin, Wenhui,Liu, Shuang,&Wu, Bin.(2013).Structural Identification of Chemical Constituents from Scutellaria baicalensis by HPLC-ESI-MS/MS and NMR Spectroscopy.ASIAN JOURNAL OF CHEMISTRY,25(7),3799-3805. |
| MLA | Lin, Wenhui,et al."Structural Identification of Chemical Constituents from Scutellaria baicalensis by HPLC-ESI-MS/MS and NMR Spectroscopy".ASIAN JOURNAL OF CHEMISTRY 25.7(2013):3799-3805. |
入库方式： OAI收割
来源：上海药物研究所
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