New Saponins from Timosaponin BIII by Acid Hydrolysis
文献类型：期刊论文
| 作者 | Liu, Zhiyu1,2; Jiang, Weixin2; Wu, Bin1; Huang, Chenggang1
|
| 刊名 | ASIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2013-05 |
| 卷号 | 25期号:5页码:2503-2505 |
| 关键词 | Rhizoma anemarrhenae Steroidal saponin Timosaponin BIII Acid hydrolysis NMR |
| ISSN号 | 0970-7077 |
| DOI | 10.14233/ajchem.2013.13428 |
| 文献子类 | Article |
| 英文摘要 | Timosaponin BIII (TBIII), a saponin isolated from the rhizome of Anemarrhena asphodeloides, exhibited potent antidepressive and anxiolytic activities in depressed mice. After administration of TBIII in rats, two main metabolites had been detected in the brain tissue, which had similar aglycone with TBIII and formed by elimination of two hexose moieties. In this study, we had hydrolyzed TBIII by some mens mid obtained 4 artificial steroidal saponins (three novel steroidal saponins: timosaponin BIII-a, timosaponin BIII-b,timosaponin BIII-c; and a known steroidal saponin timosaponin BII-b) by the dilute acid hydrolysis. Their structures were verified by means of mass, spectrometry and nuclear magnetic resonance (NMR) spectral analyses. |
| WOS关键词 | ANEMARRHENA-ASPHODELOIDES ; RHIZOMES |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2009ZX09301-001] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2009ZX09102-121] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2009ZX09501-030] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2012ZX09301001-001] ; Key and General Programs of National Natural Science Foundation of China[81030065] ; Key and General Programs of National Natural Science Foundation of China[81274055] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000317245800032 |
| 出版者 | ASIAN JOURNAL OF CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277643]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Bin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Harbin Univ Commerce, Harbin 150076, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhiyu,Jiang, Weixin,Wu, Bin,et al. New Saponins from Timosaponin BIII by Acid Hydrolysis[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(5):2503-2505. |
| APA | Liu, Zhiyu,Jiang, Weixin,Wu, Bin,&Huang, Chenggang.(2013).New Saponins from Timosaponin BIII by Acid Hydrolysis.ASIAN JOURNAL OF CHEMISTRY,25(5),2503-2505. |
| MLA | Liu, Zhiyu,et al."New Saponins from Timosaponin BIII by Acid Hydrolysis".ASIAN JOURNAL OF CHEMISTRY 25.5(2013):2503-2505. |
入库方式： OAI收割
来源：上海药物研究所
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