Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives
文献类型：期刊论文
| 作者 | Chen, Fanglei; Lei, Min ; Hu, Lihong
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2013-04-08 |
| 卷号 | 69期号:14页码:2954-2960 |
| 关键词 | Multi-component reaction Thiamine hydrochloride (VB1) Green chemistry 2-Aminobenzimidazole TMSCN |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2013.02.022 |
| 文献子类 | Article |
| 英文摘要 | An environmentally benign and efficient method has been developed for the synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives via a four-component reaction of 2-aminobenzimidazole, two molecules of aromatic aldehyde, and trimethylsilanecarbonitrile (TMSCN) in the presence of a catalytic amount of thiamine hydrochloride (VB1) in EtOH at reflux temperature. The advantages of this method are the use of an inexpensive and readily available catalyst, high yields, simple workup, and easy purification. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MANNICH-TYPE REACTION ; MULTICOMPONENT REACTIONS ; BIGINELLI REACTION ; 1,3-DICARBONYL COMPOUNDS ; PYRIMIDINE-DERIVATIVES ; BENZOIN CONDENSATION ; EFFICIENT SYNTHESIS ; UGI REACTION ; WATER ; 2-AMINOBENZIMIDAZOLE |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000316516500011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277657]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fanglei,Lei, Min,Hu, Lihong. Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives[J]. TETRAHEDRON,2013,69(14):2954-2960. |
| APA | Chen, Fanglei,Lei, Min,&Hu, Lihong.(2013).Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives.TETRAHEDRON,69(14),2954-2960. |
| MLA | Chen, Fanglei,et al."Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives".TETRAHEDRON 69.14(2013):2954-2960. |
入库方式： OAI收割
来源：上海药物研究所
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