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Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells

文献类型：期刊论文

作者Chen, Guangtong1; Yang, Xue1; Nong, Shaojun1; Yang, Min2; Xu, Bohui1; Zhang, Wei1
刊名BIOTECHNOLOGY LETTERS
出版日期2013-03
卷号35期号:3页码:439-443
ISSN号0141-5492
关键词Biotransformation Hydroperoxylation Mucor racemosus 20(S)-Protopanaxadiol
DOI10.1007/s10529-012-1098-x
文献子类Article
英文摘要Microbial transformation of 20(S)-protopanaxadiol (1) by Mucor racemosus AS 3.205 yielded two novel hydroperoxylated metabolites and three known hydroxylated metabolites. The structures of the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23,24-en-25-hydroxyl-20(S)-protopanaxadiol (3), 25,26-en-24(R)-hydroperoxyl-20(S)-protopanaxadiol (4), 23,24-en-25-hydroperoxyl-20(S)-protopanaxadiol (5), and 25-hydroxyl-20(S)-protopanaxadiol (6). 4 and 5 are new compounds. Metabolites 2, 4, and 5 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
WOS关键词DAMMARANE TRITERPENES ; MICROBIAL TRANSFORMATION ; LEUKEMIA
资助项目Natural Science Foundation of the Jiangsu Higher Education Institutions of China[10KJB350003] ; National Natural Science Foundation of China[81102327] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)[00000000]
WOS研究方向Biotechnology & Applied Microbiology
语种英语
出版者SPRINGER
WOS记录号WOS:000314788400019
源URL[http://119.78.100.183/handle/2S10ELR8/277720]  
专题上海中药现代化研究中心
通讯作者Zhang, Wei
作者单位1.Nantong Univ, Sch Med, Nantong 226001, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Guangtong,Yang, Xue,Nong, Shaojun,et al. Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells[J]. BIOTECHNOLOGY LETTERS,2013,35(3):439-443.
APA Chen, Guangtong,Yang, Xue,Nong, Shaojun,Yang, Min,Xu, Bohui,&Zhang, Wei.(2013).Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells.BIOTECHNOLOGY LETTERS,35(3),439-443.
MLA Chen, Guangtong,et al."Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells".BIOTECHNOLOGY LETTERS 35.3(2013):439-443.

入库方式： OAI收割

来源：上海药物研究所

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