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A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid

文献类型：期刊论文

作者Hu, Ling-Jun1; Zhan, Zha-Jun1; Lei, Min2; Hu, Li-Hong1,2
刊名ARKIVOC
出版日期2013
页码189-198
关键词multi-component reaction 2-carboxybenzaldehyde primary amine sulfamic acid
ISSN号1551-7004
文献子类Article
英文摘要A new and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives by a one-pot, three-component condensation reaction of 2-carboxybenzaldehyde, primary amine, and TMSCN in the presence of 10 mol% sulfamic acid (NH2SO3H) as the catalyst in EtOH under reflux temperature is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive.
WOS关键词HIV-1 REVERSE-TRANSCRIPTASE ; POTENT INHIBITORS ; ALKALOIDS ; CONDENSATION
资助项目National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD14057]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000324461400015
出版者ARKAT USA INC
源URL[http://119.78.100.183/handle/2S10ELR8/277779]  
专题上海中药现代化研究中心
通讯作者Lei, Min
作者单位1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China;
2.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Ling-Jun,Zhan, Zha-Jun,Lei, Min,et al. A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid[J]. ARKIVOC,2013:189-198.
APA Hu, Ling-Jun,Zhan, Zha-Jun,Lei, Min,&Hu, Li-Hong.(2013).A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid.ARKIVOC,189-198.
MLA Hu, Ling-Jun,et al."A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid".ARKIVOC (2013):189-198.

入库方式： OAI收割

来源：上海药物研究所

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