Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction
文献类型：期刊论文
| 作者 | Shen, Sida1; Pham Van Khang1; Chen, Yijia2; Lei, Min2 ; Hu, Lihong1,2
|
| 刊名 | ARKIVOC
 |
| 出版日期 | 2013 |
| 页码 | 413-423 |
| 关键词 | 2-cyanobenzaldehyde 3-methyl-1H-pyrazol-5(4H)-one 1,3-dimethyl-1H-pyrazol-5(4H)-one isoindolin-1-imine multi-component reaction |
| ISSN号 | 1551-7004 |
| 文献子类 | Article |
| 英文摘要 | A novel, one-pot method has been developed for the synthesis of 4-(2-substituented-3-iminoisoindolin-1-ylidene)-1-substitueted-3-methyl-1H-pyrazol-5(4H)-one derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and 3-methyl-1H-pyrazol-5(4H)-one or 1,3-dimethyl-1H-pyrazol-5(4H)-one. The efficient and convenient reaction conditions provide the corresponding products from various substrates under reflux condition in ethanol with excellent yields (85-95%). |
| WOS关键词 | NMDA RECEPTOR ANTAGONISTS ; 2-CYANOBENZALDEHYDE ; AMINES |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000324461400029 |
| 出版者 | ARKAT USA INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277780]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 2.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Sida,Pham Van Khang,Chen, Yijia,et al. Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction[J]. ARKIVOC,2013:413-423. |
| APA | Shen, Sida,Pham Van Khang,Chen, Yijia,Lei, Min,&Hu, Lihong.(2013).Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction.ARKIVOC,413-423. |
| MLA | Shen, Sida,et al."Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction".ARKIVOC (2013):413-423. |
入库方式： OAI收割
来源：上海药物研究所
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