Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines
文献类型：期刊论文
| 作者 | Chen, Guangtong2; Yang, Xue2; Zhai, Xuguang2; Yang, Min1 |
| 刊名 | BIOTECHNOLOGY LETTERS
 |
| 出版日期 | 2013-01 |
| 卷号 | 35期号:1页码:91-95 |
| 关键词 | Absidia corymbifera Biotransformation Cytotoxic activity 20(S)-Protopanaxatriol |
| ISSN号 | 0141-5492 |
| DOI | 10.1007/s10529-012-1053-x |
| 文献子类 | Article |
| 英文摘要 | Seven hydroxylates of 20(S)-protopanaxatriol (1) transformed by Absidia corymbifera AS 3.3387 were isolated and identified by spectral methods including 2D-NMR. Among them, 7 beta-hydroxyl-20(S)-protopanaxatriol (2), 7 alpha-hydroxyl-20(S)-protopanaxatriol (3), and 7 beta, 15 alpha-dihydroxyl-20(S)-protopanaxatriol (7) are new compounds. The metabolites 2, 6, 7, and 8 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate. |
| WOS关键词 | GINSENOSIDES ; LEUKEMIA ; GINSENG |
| 资助项目 | National Natural Science Foundation of China[81102327] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)[00000000] |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000312060200011 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277833]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Yang, Min |
| 作者单位 | 1.Chinese Acad Sci, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr TCM Modernizat, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Nantong Univ, Sch Med, Nantong 226001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guangtong,Yang, Xue,Zhai, Xuguang,et al. Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines[J]. BIOTECHNOLOGY LETTERS,2013,35(1):91-95. |
| APA | Chen, Guangtong,Yang, Xue,Zhai, Xuguang,&Yang, Min.(2013).Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines.BIOTECHNOLOGY LETTERS,35(1),91-95. |
| MLA | Chen, Guangtong,et al."Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines".BIOTECHNOLOGY LETTERS 35.1(2013):91-95. |
入库方式： OAI收割
来源：上海药物研究所
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