Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues
文献类型：期刊论文
| 作者 | Hu, Lingjun2; Song, Weibin1; Meng, Yuhui1; Guo, Dean1 ; Liu, Xuan1; Hu, Lihong1,2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2012-12-15 |
| 卷号 | 22期号:24页码:7547-7550 |
| 关键词 | Vinorelbine C-22 amide analogues Tubulin inhibitor Structure-activity relationship (SAR) Cytotoxicity |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.10.024 |
| 文献子类 | Article |
| 英文摘要 | A series of 3-demethoxycarbonyl-3-acylamide methyl vinorelbine derivatives (compounds 7a-7z) were designed, synthesized, and evaluated for their inhibition activities against human non-small cell lung cancer cell line (A549). Most of the amide derivatives exhibited potent cytotoxicity, with the size of the introduced substituents being the foremost factor in determining the resultant cytotoxic activity. Test results in vivo against nude mice bearing A549 xenografts indicated that 7y showed comparable activities compared to the parent NVB. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DIMERIC CATHARANTHUS ALKALOIDS ; VINCA ALKALOIDS ; COUPLING REACTION ; ANHYDROVINBLASTINE ANALOGS ; VINBLASTINE ; VINDOLINE ; DERIVATIVES ; MECHANISM ; ROSEUS ; TARGET |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273430] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD14057] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000311425500053 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277843]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Lingjun,Song, Weibin,Meng, Yuhui,et al. Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(24):7547-7550. |
| APA | Hu, Lingjun,Song, Weibin,Meng, Yuhui,Guo, Dean,Liu, Xuan,&Hu, Lihong.(2012).Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(24),7547-7550. |
| MLA | Hu, Lingjun,et al."Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.24(2012):7547-7550. |
入库方式： OAI收割
来源：上海药物研究所
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