Metabolism studies of casticin in rats using HPLC-ESI-MSn
文献类型：期刊论文
| 作者 | Ling, Yun1; Zhu, Jianyong2; Fan, Mingsong1; Wu, Bin1; Qin, Luping2; Huang, Chenggang1
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
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| 出版日期 | 2012-12 |
| 卷号 | 26期号:12页码:1502-1508 |
| 关键词 | casticin LC-ESI-MSn rat metabolites |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.2724 |
| 文献子类 | Article |
| 英文摘要 | Casticin (3',5-dihydroxy-3, 4',6,7-tetramethoxyflavone) has been revealed to possess various kinds of pharmacological activities, including immunomodulatory, anti-hyperprolactinemia, anti-tumor and neuroprotetective activities. In order to gain an understanding of the biotransformation of casticin in vivo, a systematic method based on liquid chromatographyelectrospray ionization tandem mass spectrometry (LC-ESI-MSn) was developed to identify the metabolites of casticin in rats after oral administration of single dose of casticin at 200?mg/kg. By comparing their changes in molecular masses (Delta M), retention times and spectral patterns with those of the parent drug, the parent compound and 25 metabolites were identified in rat plasma, urine and six selected tissues. This is the first systematic metabolism study of casticin in vivo. The results indicated that methylation, demethylation, glucuronidation and sulfation were the main biotransformation pathways of casticin in vivo. Copyright (c) 2012 John Wiley & Sons, Ltd. |
| WOS关键词 | IN-VITRO ; FLAVONOID CASTICIN ; IDENTIFICATION ; VIVO |
| 资助项目 | National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09301-001] ; National science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09501-030] ; National science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09103-373] ; National science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZXJ09004-068] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000310078600007 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277871]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Chenggang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ling, Yun,Zhu, Jianyong,Fan, Mingsong,et al. Metabolism studies of casticin in rats using HPLC-ESI-MSn[J]. BIOMEDICAL CHROMATOGRAPHY,2012,26(12):1502-1508. |
| APA | Ling, Yun,Zhu, Jianyong,Fan, Mingsong,Wu, Bin,Qin, Luping,&Huang, Chenggang.(2012).Metabolism studies of casticin in rats using HPLC-ESI-MSn.BIOMEDICAL CHROMATOGRAPHY,26(12),1502-1508. |
| MLA | Ling, Yun,et al."Metabolism studies of casticin in rats using HPLC-ESI-MSn".BIOMEDICAL CHROMATOGRAPHY 26.12(2012):1502-1508. |
入库方式： OAI收割
来源：上海药物研究所
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