Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction
文献类型：期刊论文
| 作者 | Jiang, Weixin2; Jin, Di1,2; Li, Zhixiong1 ; Sun, Zhaolin1; Chen, Mingcang1; Wu, Bin1; Huang, Chenggang1
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2012-07 |
| 卷号 | 26期号:7页码:863-868 |
| 关键词 | Paederia scandens HPLC-MSn metabolites iridoid glucosides urine serum |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.1743 |
| 文献子类 | Article |
| 英文摘要 | Paederia scandens (Lour.) Merri. (Jishiteng in Chinese) is a Chinese traditional medicine widely used in treating various diseases. However, its active components have remained unknown. In the present study, a rapid and sensitive method by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-MSn) techniques was employed to investigate the absorbed constituents in rats after oral administration of Paederia scandens decoction. By comparing their MS data with those of authentic compounds and published data, a total of six compounds (paederosid, 1; paederosidic acid, 2; paederosidic acid methyl ester, 3; 6-hydroxy geniposide, 4; asperuloside, 5; and deacetyl asperuloside, 6) were identified in the P. scandens decoction samples. In addition, a total of seven compounds, including three iridoid glucosides and four of their metabolites, were identified in rat urine samples after administration. In addition, six compounds, including four iridoid glucosides and two of their metabolites, were identified in rat serum samples after administration. Our results significantly narrow the range of potentially active compounds in P. scandens decoction, and build a solid foundation for future research on its mechanism. Copyright (c) 2011 John Wiley & Sons, Ltd. |
| WOS关键词 | IONIZATION-MASS-SPECTROMETRY ; LC-MS/MS ; MAJOR METABOLITES ; IDENTIFICATION ; URINE ; MS ; SAPONINS ; EXTRACT ; SERUM |
| 资助项目 | National Science and Technology Major Project 'Key New Drug Creationand Manufacturing Program', China[2009ZX09301-001] ; Science and Technology Commission of Shanghai Municipality[08DZ1971402] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000304989300013 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278035]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Chenggang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Harbin Univ Commerce, Harbin 150076, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Weixin,Jin, Di,Li, Zhixiong,et al. Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction[J]. BIOMEDICAL CHROMATOGRAPHY,2012,26(7):863-868. |
| APA | Jiang, Weixin.,Jin, Di.,Li, Zhixiong.,Sun, Zhaolin.,Chen, Mingcang.,...&Huang, Chenggang.(2012).Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction.BIOMEDICAL CHROMATOGRAPHY,26(7),863-868. |
| MLA | Jiang, Weixin,et al."Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction".BIOMEDICAL CHROMATOGRAPHY 26.7(2012):863-868. |
入库方式： OAI收割
来源：上海药物研究所
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