Studies on the fragmentation pathways of ingenol esters isolated from Euphorbia esula using IT-MSn and Q-TOF-MS/MS methods in electrospray ionization mode
文献类型：期刊论文
| 作者 | Yang, Min1; Lu, Zhiqiang1; Yu, Kate2; Wang, Qiurong1; Chen, Xin1; Li, Yifeng1; Liu, Xuan1; Wu, Wanying1 ; Guo, De-an1
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| 刊名 | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 323页码:55-62 |
| 关键词 | Diterpenoids Ingenol esters Tandem mass spectrometry Ion trap Q-TOF-MS/MS |
| ISSN号 | 1387-3806 |
| DOI | 10.1016/j.ijms.2012.07.006 |
| 文献子类 | Article |
| 英文摘要 | Ingenol esters, one type of diterpenoids isolated from genus Euphorbia, were reported to possess cytotoxic activities. In our previous study, a number of ingenol esters were isolated from Euphorbia esula L. (Ru-Jiang-Da-Ji in Chinese). And as a part of the ongoing program, a study of fragmentation pathway of ingenol esters was carried out using mass spectrometry. The fragmentation behaviors of 17 standard compounds were investigated with ion trap (IT-MSn) mass spectrometry and hybrid quadrupole-time of flight-mass spectrometer (Q-TOF-MS/MS) in positive ion mode. Electrospray ionization (ESI) was used as ion source in analysis. According to the IT-MSn spectra, the elimination order of the acyloxy was R1OH > R2H > R3H > R4H, which was hard to determine in Q-TOF-MS/MS spectra. The Q-TOF-MS preferred to eliminate all the acyloxys along with some hydroxyls and produce three characteristic ions (x(0), y(0). z(0)), which indicate the numbers of the oxygenated groups. The Q-TOF-MS also provide high resolution mass spectra of the parent and product ions, which allowed the determination of the chemical formulas and characterization of the ion structures. These two instruments gave complementary information, which were very useful for structural characterization of the studied compounds. (C) 2012 Elsevier B.V. All rights reserved. |
| WOS关键词 | FLIGHT MASS-SPECTROMETRY ; MACROCYCLIC DITERPENE ; CHEMICAL-IONIZATION ; SAPONINS ; JATROPHANE |
| 资助项目 | National Natural Science Foundation of China[81001630] ; Natural Science Foundation of Shanghai[10ZR1436400] |
| WOS研究方向 | Physics ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000308768400010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278045]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China; 2.Waters Corp, Milford, MA 01757 USA |
| 推荐引用方式 GB/T 7714 | Yang, Min,Lu, Zhiqiang,Yu, Kate,et al. Studies on the fragmentation pathways of ingenol esters isolated from Euphorbia esula using IT-MSn and Q-TOF-MS/MS methods in electrospray ionization mode[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2012,323:55-62. |
| APA | Yang, Min.,Lu, Zhiqiang.,Yu, Kate.,Wang, Qiurong.,Chen, Xin.,...&Guo, De-an.(2012).Studies on the fragmentation pathways of ingenol esters isolated from Euphorbia esula using IT-MSn and Q-TOF-MS/MS methods in electrospray ionization mode.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,323,55-62. |
| MLA | Yang, Min,et al."Studies on the fragmentation pathways of ingenol esters isolated from Euphorbia esula using IT-MSn and Q-TOF-MS/MS methods in electrospray ionization mode".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 323(2012):55-62. |
入库方式： OAI收割
来源：上海药物研究所
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