Study of Luan-Pao-Prescription on ovarian dysfunction in rats
文献类型：期刊论文
| 作者 | Jiang, Baohong2 ; Sun, Kejia2; Li, Ming2; Wang, Yanling3; Zhuang, Lingzhi3; Zhang, Lin2; Wang, Yingchun2; Liu, Xuan2; Wu, Wanying2; Guan, Shuhong2
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| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 141期号:2页码:653-658 |
| 关键词 | Luan-Pao-Prescription Infertility Ovarian dysfunction |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2011.08.082 |
| 文献子类 | Article |
| 英文摘要 | Ethnopharmacological relevance: Luan-Pao-Prescription (LPP) has been clinically proven to be effective on infertility. In the present study we explored the improvement and underlying mechanism of LPP on ovarian dysfunction in rats. Materials and methods: 13 month old female rats were randomly divided into 4 groups: the Saline group, the LPP groups treated by low (1.67 g/kg), and high-dose (5 g/kg) LPP respectively, and the hormone group treated by pregnant mare gonadotrophin serum and chorionic gonadotrophin (PMSG/hCG). The estrous cycle was determined by daily observation of vaginal smears; serum estradiol and testosterone were estimated by enzyme-linked immunosorbent assay; ovarian morphology, ovary volume and fertility of female rats were all detected during the study. Results: During 21 days of LPP treatment, about 20% increase of rats with regular estrous cycle of 4-6 days was found, but no change was detected on serum estradiol and testosterone at the dose of 1.67 g/kg and 5 g/kg LPP. Both ovary index and uterus index were up-regulated significantly at the dose of 5 g/kg LPP, but no regulation on oviduct index, adrenal gland index, pancreatic gland index and spleen index was observed at the two LPP groups. 5 g/kg LPP increased total number of pregnant mothers and the offspring; however there are no offspring in PMSG/hCG group. The offspring exhibited similar body weight in each treatment, and no apparent malformation was found for the cubs. While PMSG/hCG treatment increased the ovary index, serum estradiol and testosterone concentration considerably, but no improvement was found on estrous cycle, oviduct index, uterus index, and reproduction. Conclusion: Administration of LPP may have comparable benefits for ovarian dysfunction, but with fewer side effects. Oral LPP have a better overall influence on rats than PSMG/hCG; it may be more effective in improvement of estrous cycle, ovary function and reproduction. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | FEMALE INFERTILITY ; CONSTITUENTS ; DISORDERS ; HEALTH ; TRIAL |
| 资助项目 | National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09308-005] ; National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09102-122] ; National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX090304-002] ; National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09311-001] ; National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09502-020] ; Chinese Academy of Sciences[KSCX2-YW-R-166] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000305201100017 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278048]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Yu, Jin |
| 作者单位 | 1.Shanghai Kuntai Hosp Chinese Med, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Baohong,Sun, Kejia,Li, Ming,et al. Study of Luan-Pao-Prescription on ovarian dysfunction in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2012,141(2):653-658. |
| APA | Jiang, Baohong.,Sun, Kejia.,Li, Ming.,Wang, Yanling.,Zhuang, Lingzhi.,...&Dean-Guo.(2012).Study of Luan-Pao-Prescription on ovarian dysfunction in rats.JOURNAL OF ETHNOPHARMACOLOGY,141(2),653-658. |
| MLA | Jiang, Baohong,et al."Study of Luan-Pao-Prescription on ovarian dysfunction in rats".JOURNAL OF ETHNOPHARMACOLOGY 141.2(2012):653-658. |
入库方式： OAI收割
来源：上海药物研究所
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