The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues
文献类型：期刊论文
| 作者 | Song, Weibin1,2; Hu, Lingjun3; Meng, Yuhui1; Ma, Lei2; Guo, Dean1 ; Liu, Xuan1; Hu, Lihong1,2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2012-05-15 |
| 卷号 | 22期号:10页码:3485-3487 |
| 关键词 | C-16 substituent effects Vinorelbine analogues Biomimetic coupling Structure-activity relationship (SAR) Cytotoxicity |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.03.082 |
| 文献子类 | Article |
| 英文摘要 | A new series of vinorelbine analogues are designed and synthesized to explore the vindoline C-16 substituent effects on the biomimetic coupling with catharanthine, and the structure-activity relationships of these vinorelbine analogues as cytotoxic agents are also studied. The results show that introduction of severe steric hindrance and/or electron-withdrawing group at C-16 site are not propitious to improving the yields of the coupling reaction, and the SAR information collected so far suggests that small alkyl groups substituted at C-16 of vindoline are conductive to maintaining the cytotoxicity. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DIMERIC CATHARANTHUS ALKALOIDS ; VINCA ALKALOIDS ; ANHYDROVINBLASTINE ANALOGS ; DERIVATIVES ; VINFLUNINE ; SERIES ; TARGET ; ROSEA |
| 资助项目 | National Natural Science Foundation of China[2009ZX09102-022] ; National Natural Science Foundation of China[30925040] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000303545900019 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278077]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Weibin,Hu, Lingjun,Meng, Yuhui,et al. The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(10):3485-3487. |
| APA | Song, Weibin.,Hu, Lingjun.,Meng, Yuhui.,Ma, Lei.,Guo, Dean.,...&Hu, Lihong.(2012).The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(10),3485-3487. |
| MLA | Song, Weibin,et al."The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.10(2012):3485-3487. |
入库方式： OAI收割
来源：上海药物研究所
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