Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens
文献类型：期刊论文
| 作者 | Jin, Di1,2; Li, Zhixiong1 ; Chen, Mingcang1; Fan, Mingsong1; Sun, Zhaolin1; Jiang, Weixin2; Wu, Bin1; Huang, Chenggang1
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| 刊名 | ASIAN JOURNAL OF CHEMISTRY
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| 出版日期 | 2012-02 |
| 卷号 | 24期号:2页码:538-540 |
| 关键词 | Paederia scandens Sulfur-containing iridoid glucosides Paederoside Paederosidic acid Paederosidic acid methyl ester Antinociceptive activity Spectroscopic analysis |
| ISSN号 | 0970-7077 |
| 文献子类 | Article |
| 英文摘要 | Isolate and purify the sulfur-containing iridoid glucosides from Paederia scandens. Three sulfur-containing iridoid glucosides (1-3) were isolated and the structures of them were elucidated as paederosides (1), paederosidic acid (2) and paederosidic acid methyl ester (3) by spectroscopic analysis. The sulfur-containing iridoid glucosides were evaluated on antinociceptive activity in mice using thermal models of nociception. Both paederosidic acid (2, 120 mg/kg. i.g. or 70 mg/kg, i.p.) and paederosidic acid methyl ester (3, 70 mg/kg, i.p.) produced significant inhibitory activity on thermal nociception in the hot plate test. Paederoside (1, 70 mg/kg, i.p.) had not produced significant antinociceptive effects in the hot plate test. |
| WOS关键词 | MONOTERPENE GLUCOSIDES |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX093 08-005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300464000013 |
| 出版者 | ASIAN JOURNAL OF CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278194]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Bin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Harbin Univ Commerce, Harbin 150076, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Di,Li, Zhixiong,Chen, Mingcang,et al. Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens[J]. ASIAN JOURNAL OF CHEMISTRY,2012,24(2):538-540. |
| APA | Jin, Di.,Li, Zhixiong.,Chen, Mingcang.,Fan, Mingsong.,Sun, Zhaolin.,...&Huang, Chenggang.(2012).Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens.ASIAN JOURNAL OF CHEMISTRY,24(2),538-540. |
| MLA | Jin, Di,et al."Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens".ASIAN JOURNAL OF CHEMISTRY 24.2(2012):538-540. |
入库方式： OAI收割
来源：上海药物研究所
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