Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-alpha Expression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury
文献类型：期刊论文
| 作者 | Peng, Jing-Hua1,2; Cui, Tuan1; Sun, Zhao-Lin3; Huang, Fu1,2; Chen, Liang1,2; Xu, Lin1,2; Feng, Qin1,2; Hu, Yi-Yang1,2,4 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2012 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2012/234987 |
| 文献子类 | Article |
| 英文摘要 | Kudzu (Pueraria lobata) is one of the earliest medicinal plants used to treat alcohol abuse in traditional Chinese medicine for more than a millennium. However, little is known about its effects on chronic alcoholic liver injury. Therefore, the present study observed the effects of puerariae radix extract (RPE) on chronic alcoholic liver injury as well as Kupffer cells (KCs) activation to release tumor necrosis factor alpha (TNF-alpha) induced by gut-derived endotoxin in rats and macrophage cell line. RPE was observed to alleviate the pathological changes and lipids deposition in liver tissues as well as the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic gamma-glutamyl transpeptidase (GGT) activity. Meanwhile, RPE inhibited KCs activation and subsequent hepatic TNF-alpha expression and downregulated the protein expression of endotoxin receptors, lipopolysaccharide binding protein (LBP), CD14, Toll-like receptor (TLR) 2, and TLR4 in chronic alcohol intake rats. Furthermore, an in vitro study showed that RPE inhibited the expression of TNF-alpha and endotoxin receptors, CD14 and TLR4, induced by LPS in RAW264.7 cells. In summary, this study demonstrated that RPE mitigated liver damage and lipid deposition induced by chronic alcohol intake in rats, as well as TNF-alpha release, protein expression of endotoxin receptors in vivo or in vitro. |
| WOS关键词 | LIPOPOLYSACCHARIDE-BINDING PROTEIN ; KUPFFER CELL ACTIVATION ; SYRIAN GOLDEN-HAMSTERS ; RECEIVING FREE-ACCESS ; INTESTINAL PERMEABILITY ; ALDEHYDE DEHYDROGENASE ; WITHDRAWAL SYMPTOMS ; MONOAMINE-OXIDASE ; VOLUNTARY ALCOHOL ; ETHANOL INTAKE |
| 资助项目 | National Natural Science Foundation of China[81001575] ; Leading Academic Discipline of Hepatology of State Administration of TCM China[2010sh] ; Shanghai Municipal Education Commission[00000000] |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000310611200001 |
| 出版者 | HINDAWI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278237]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Yi-Yang |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Minist Educ, Key Lab Liver & Kidney Dis, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Shanghai Municipal Educ Commiss, E Inst TCM Internal Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Jing-Hua,Cui, Tuan,Sun, Zhao-Lin,et al. Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-alpha Expression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012. |
| APA | Peng, Jing-Hua.,Cui, Tuan.,Sun, Zhao-Lin.,Huang, Fu.,Chen, Liang.,...&Hu, Yi-Yang.(2012).Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-alpha Expression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Peng, Jing-Hua,et al."Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-alpha Expression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012). |
入库方式： OAI收割
来源：上海药物研究所
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