Bioactivity-guided Fractionation and Analysis of Compounds with Anti-influenza Virus Activity from Gardenia jasminoides Ellis
文献类型：期刊论文
| 作者 | Yang, Quanjun2; Wu, Bin2; Shi, Yujing1; Du, Xiaowei3; Fan, Mingsong2; Sun, Zhaolin2; Cui, Xiaolan1; Huang, Chenggang2
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2012-01 |
| 卷号 | 35期号:1页码:9-17 |
| 关键词 | Bioassay-guided fractionation HPLC-PDA-ESI-MS/MS Fragmentation behavior Anti-influenza |
| ISSN号 | 0253-6269 |
| DOI | 10.1007/s12272-012-0101-3 |
| 文献子类 | Article |
| 英文摘要 | Bioassay-guided fractionation of extracts from Fructus Gardeniae led to analysis of its bioactive natural products. After infection by influenza virus strain A/FM/1/47-MA in, vivo, antiviral activity of the extracts were investigated. The target fraction was orally administered to rats and blood was collected. High-performance liquid chromatography coupled with photo diode array detector and electrospray ion trap multiple-stage tandem mass spectrometry was applied to screen the compounds absorbed into the blood. A structural characterization based on the retention time, ultraviolet spectra, parent ions and fragmentation ions was performed. Thirteen compounds were confirmed or tentatively identified. This provides an accurate profile of the composition of bioactive compounds responsible for the anti-influenza properties. |
| WOS关键词 | RESPIRATORY SYNCYTIAL VIRUS ; MASS-SPECTROMETRY ; ACID-DERIVATIVES ; CONSTITUENTS ; GENIPOSIDE ; GLYCOSIDE ; IRIDOIDS ; FRUCTUS ; MS/MS ; FRUIT |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09308-005] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09103-373] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000299757300003 |
| 出版者 | PHARMACEUTICAL SOC KOREA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278276]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Cui, Xiaolan |
| 作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Med, Beijing 100029, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Heilongjiang Univ Chinese Med, Harbin 150040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Quanjun,Wu, Bin,Shi, Yujing,et al. Bioactivity-guided Fractionation and Analysis of Compounds with Anti-influenza Virus Activity from Gardenia jasminoides Ellis[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(1):9-17. |
| APA | Yang, Quanjun.,Wu, Bin.,Shi, Yujing.,Du, Xiaowei.,Fan, Mingsong.,...&Huang, Chenggang.(2012).Bioactivity-guided Fractionation and Analysis of Compounds with Anti-influenza Virus Activity from Gardenia jasminoides Ellis.ARCHIVES OF PHARMACAL RESEARCH,35(1),9-17. |
| MLA | Yang, Quanjun,et al."Bioactivity-guided Fractionation and Analysis of Compounds with Anti-influenza Virus Activity from Gardenia jasminoides Ellis".ARCHIVES OF PHARMACAL RESEARCH 35.1(2012):9-17. |
入库方式： OAI收割
来源：上海药物研究所
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