Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice
文献类型：期刊论文
| 作者 | Tang, Yi Hong1,2; Sun, Zhao Lin1; Fan, Ming Song1; Li, Zhi Xiong1; Huang, Cheng Gang1 |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2012-01 |
| 卷号 | 78期号:1页码:18-23 |
| 关键词 | TongGuanWan herbal formula type 2 diabetes anti-diabetic effect |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0031-1280268 |
| 文献子类 | Article |
| 英文摘要 | In the present study, the anti-diabetic effects of a traditional Chinese medicinal formula extract, TongGuanWan, were investigated in type 2 diabetic animals. It was orally administered to C57BL/KsJ-db/db mice once a day for 4 weeks at the doses of 62, 125, and 250 mg/kg body weight. TongGuanWan significantly lowered the blood glucose and glycosylated haemoglobin levels as well as improved the glucose tolerance in db/db mice. The serum triglyceride levels in the db/db mice were significantly decreased, whereas the high-density lipoprotein cholesterol levels were significantly increased, after treatment with this herbal formula. TongGuanWan also markedly decreased the animals 'body weights compared to those of the control db/db group but did not alter food intake. The effects of TongGuanWan were compared to those of the drug rosiglitazone. In addition, five main constituents of TongGuanWan, mangiferin, berberine, cinnamic aldehyde, timosaponin BII, and timosaponin AIII, were quantified using high performance liquid chromatography coupled with a diode array and an evaporative light scattering detector (HPLC-DAD-ELSD). These results suggest that TongGuanWan may be useful for the treatment of type 2 diabetes. |
| WOS关键词 | INDUCED DIABETIC-RATS ; INSULIN-RESISTANCE ; HYPERGLYCEMIA ; PATHOGENESIS ; MANGIFERIN ; EXTRACT |
| 资助项目 | National Natural Science Foundation of China[20805054] ; National Natural Science Foundation of China[81030065] ; Science and Technology Commission of Shanghai Municipality[08DZ1971402] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000299109700004 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278286]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng Gang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yi Hong,Sun, Zhao Lin,Fan, Ming Song,et al. Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice[J]. PLANTA MEDICA,2012,78(1):18-23. |
| APA | Tang, Yi Hong,Sun, Zhao Lin,Fan, Ming Song,Li, Zhi Xiong,&Huang, Cheng Gang.(2012).Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice.PLANTA MEDICA,78(1),18-23. |
| MLA | Tang, Yi Hong,et al."Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice".PLANTA MEDICA 78.1(2012):18-23. |
入库方式： OAI收割
来源：上海药物研究所
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