Biotransformation of pseudolaric acid B by Chaetomium globosum
文献类型：期刊论文
| 作者 | Zhang, Xing2,4; Ye, Min2; Gong, Yu-jing1; Feng, Lin-Min2; Tao, Si-Jia3; Yin, Jun4; Guo, De-an2,3
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| 刊名 | PROCESS BIOCHEMISTRY
 |
| 出版日期 | 2011-10 |
| 卷号 | 46期号:10页码:2064-2067 |
| 关键词 | Biotransformation Chaetomium globosum Pseudolaric acid B Antifungal activity Candida albicans |
| ISSN号 | 1359-5113 |
| DOI | 10.1016/j.procbio.2011.07.019 |
| 文献子类 | Article |
| 英文摘要 | Pseudolaric acid B (1) is a natural product with potent antifungal activity. We discovered that pseudolaric acid B did not kill but only suppress the growth of the filamentous fungus Chaetomium globosum. It was proposed that pseudolaric acid B was converted to metabolites with decreased antifungal activities. In this study, a scaled-up biotransformation of pseudolaric acid B by C. globosum produced five metabolites, including three new compounds, pseudolaric acid I (2), pseudolaric acid B 18-oyl-alanine (4) and pseudolaric acid B 18-oyl-serine (6), together with two known compounds, pseudolaric acid F (3) and pseudolaric acid B 18-oyl-glycine (5). The structures were characterized by NMR and MS spectroscopy. The major biotransformation reaction was conjugation with amino acids. None of the metabolites showed inhibitory effects on the growth of Candida albicans. The results suggested that biotransformation might be a detoxification process for fungi to resist antifungal drugs. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SIGNALING PATHWAY ; DITERPENOIDS ; ACTIVATION ; APOPTOSIS ; KAEMPFERI ; ARREST ; CELLS |
| 资助项目 | Peking University Health Science Center[985-2-119-121] ; Beijing Natural Science Foundation[7102103] ; Beijing NOVA Program[2009B02] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000295913700024 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278385]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ye, Min |
| 作者单位 | 1.China Acad Chinese Med Sci, Expt Res Ctr, Beijing 100700, Peoples R China; 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 3.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xing,Ye, Min,Gong, Yu-jing,et al. Biotransformation of pseudolaric acid B by Chaetomium globosum[J]. PROCESS BIOCHEMISTRY,2011,46(10):2064-2067. |
| APA | Zhang, Xing.,Ye, Min.,Gong, Yu-jing.,Feng, Lin-Min.,Tao, Si-Jia.,...&Guo, De-an.(2011).Biotransformation of pseudolaric acid B by Chaetomium globosum.PROCESS BIOCHEMISTRY,46(10),2064-2067. |
| MLA | Zhang, Xing,et al."Biotransformation of pseudolaric acid B by Chaetomium globosum".PROCESS BIOCHEMISTRY 46.10(2011):2064-2067. |
入库方式： OAI收割
来源：上海药物研究所
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