Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata
文献类型：期刊论文
| 作者 | Zhang, Xing1,4; Ye, Min1; Dong, Yin-hui2; Hu, Hong-bo2; Tao, Si-jia3; Yin, Jun4; Guo, De-an1,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2011-10 |
| 卷号 | 72期号:14-15页码:1779-1785 |
| 关键词 | Saussurea involucrata Asterates Biotransformation Bufadienolides Cell suspension culture Cytotoxicity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2011.05.004 |
| 文献子类 | Article |
| 英文摘要 | The biotransformation of three bioactive bufadienolides, namely, bufotalin (1), telocinobufagin (2), and gamabufotalin (3) by cell suspension cultures of Saussurea involucrata yielded 11 products. Bufotalin yielded 3-epi-bufotalin (1a), 3-epi-desacetylbufotalin (1b), 3-epi-bufotalin 3-O-beta-D-glucoside (1c), 1 beta-hydroxybufotalin (1d), and 5 beta-hydroxybufotalin (1e); telocinobufagin yielded 3-dehydroscillarenin (2a), 3-dehydrobufalin (2b), and 3-epi-telocinobufagin (2c); and gamabufotalin yielded 3-epi-gamabufotalin (3a), 3-dehydrogamabufotalin (3b), and 3-dehydro-Delta(1)-gamabufotalin (3c), respectively. Among these 11 products, 1a, 1b, 1c, 1d, 3a and 3c are previously unreported. The structures of these metabolites were elucidated based on NMR spectroscopic analyses and mass spectrometry. Most metabolites showed significant cytotoxic activities against human hepatoma (HepG2) and breast cancer (MCF-7) cell lines. In addition, the time course for the biotransformation of 3 was investigated. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CYTOTOXIC BUFADIENOLIDES ; MICROBIAL HYDROXYLATION ; CATHARANTHUS-ROSEUS ; CINOBUFAGIN ; BUFALIN ; 12-BETA-HYDROXYLATION ; APOPTOSIS |
| 资助项目 | Peking University Health Science Center[985-2-119-121] ; Beijing Nova Program[2009802] ; Specialized Research Fund for the Doctoral Program of Higher Education of China[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000294973300009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278392]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ye, Min |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China; 3.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Dept Pharmacognosy, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xing,Ye, Min,Dong, Yin-hui,et al. Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata[J]. PHYTOCHEMISTRY,2011,72(14-15):1779-1785. |
| APA | Zhang, Xing.,Ye, Min.,Dong, Yin-hui.,Hu, Hong-bo.,Tao, Si-jia.,...&Guo, De-an.(2011).Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata.PHYTOCHEMISTRY,72(14-15),1779-1785. |
| MLA | Zhang, Xing,et al."Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata".PHYTOCHEMISTRY 72.14-15(2011):1779-1785. |
入库方式： OAI收割
来源：上海药物研究所
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