Quality assessment for fructus Gardeniae by multi-component quantification, chromatographic fingerprint and related chemometric analysis
文献类型：期刊论文
| 作者 | Yang, Quanjun1,2; Fan, Mingsong2; Wu, Bin2; Sun, Zhaolin2; Cui, Xiaolan3; Du, Xiaowei1; Huang, Chenggang2
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| 刊名 | JOURNAL OF MEDICINAL PLANTS RESEARCH
 |
| 出版日期 | 2011-09-09 |
| 卷号 | 5期号:17页码:4126-4137 |
| 关键词 | Fructus Gardeniae chromatographic fingerprint multi-component quantification principal component analysis hierachical cluster analysis |
| ISSN号 | 1996-0875 |
| 文献子类 | Article |
| 英文摘要 | A simple, feasible and effective method of ultra performance liquid chromatography (UPLC) coupled with photo diode array (PDA) were established for fingerprint analysis and simultaneous quantification of three major classes of constitutions including iridoid glycosides, crocins and organic acids of fructus Gardeniae. Extraction method was optimized as 75% methanol ultrasonic extraction for 30 min. Acetonitrile-water (containing 0.2% formic acid) gradient elution on Waters Acquity BEH C18 column (50 x 2.1 mm, 1.7 mu m) was used to obtain good chromatographic resolution. 24 characteristic peaks were comprised in the fingerprint common pattern. Among them, seven marked components, geniposide, shanzhiside methyl ester, geinpin, geniposidic acid, crocin I, crocin II, and chlorogenic acid, were quantified. Similarity evaluation, principal component analysis and hierachical cluster analysis were applied to demonstrate the distinction. It was concluded that chemical components of Gardenia jasminoides Eills and Gardenia jasminoides var. radicans Makino from different origins were similar. Other than determination of the content of geniposide and crocin I, comparison of fingerprint atlas could be considered as a suitable quality control method for fructus Gardeniae. |
| WOS关键词 | TRADITIONAL CHINESE MEDICINES ; MASS-SPECTROMETRY ; JASMINOIDES ; GENIPOSIDE ; CROCIN ; FRUIT ; HPLC |
| 资助项目 | China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs[2009ZX09301-001] ; China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs[2009ZX09308-005] ; China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs[2009ZX09103-373] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000297465300020 |
| 出版者 | ACADEMIC JOURNALS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278404]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Du, Xiaowei |
| 作者单位 | 1.Heilongjiang Univ Chinese Med, Coll Pharm, Harbin 150040, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.China Acad Chinese Med Sci, Inst Chinese Med, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Quanjun,Fan, Mingsong,Wu, Bin,et al. Quality assessment for fructus Gardeniae by multi-component quantification, chromatographic fingerprint and related chemometric analysis[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2011,5(17):4126-4137. |
| APA | Yang, Quanjun.,Fan, Mingsong.,Wu, Bin.,Sun, Zhaolin.,Cui, Xiaolan.,...&Huang, Chenggang.(2011).Quality assessment for fructus Gardeniae by multi-component quantification, chromatographic fingerprint and related chemometric analysis.JOURNAL OF MEDICINAL PLANTS RESEARCH,5(17),4126-4137. |
| MLA | Yang, Quanjun,et al."Quality assessment for fructus Gardeniae by multi-component quantification, chromatographic fingerprint and related chemometric analysis".JOURNAL OF MEDICINAL PLANTS RESEARCH 5.17(2011):4126-4137. |
入库方式： OAI收割
来源：上海药物研究所
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