Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network
文献类型：期刊论文
| 作者 | Xu, Lingling1; Deng, Yanping1; Feng, Lixin1; Li, Defang1; Chen, Xiaoyan1 ; Ma, Chao1; Liu, Xuan1; Yin, Jun2; Yang, Min1; Teng, Fukang1,2
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| 刊名 | PLOS ONE
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| 出版日期 | 2011-09-06 |
| 卷号 | 6期号:9 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0024036 |
| 文献子类 | Article |
| 英文摘要 | Targeting cellular function as a system rather than on the level of the single target significantly increases therapeutic potency. In the present study, we detect the target pathway of salvianolic acid B (SalB) in vivo. Acute myocardial infarction (AMI) was induced in rats followed by the treatment with 10 mg/kg SalB. Hemodynamic detection and pathological stain, 2-dimensional electrophoresis, MALDI-TOF MS/MS, Western blot, pathway identification, apoptosis assay and transmission electron microscope were used to elucidate the effects and mechanism of SalB on cardioprotection. Higher SalB concentration was found in ischemic area compared to no-ischemic area of heart, correlating with improved heart function and histological structure. Thirty-three proteins regulated by SalB in AMI rats were identified by biochemical analysis and were classified as the components of metabolism and apoptosis networks. SalB protected cardiomyocytes from apoptosis, inhibited poly (ADP-ribose) polymerase-1 pathway, and improved the integrity of mitochondrial and nucleus of heart tissue during AMI. Furthermore, the protective effects of SalB against apoptosis were verified in H9c2 cells. Our results provide evidence that SalB regulates multi-targets involved in the apoptosis pathway during AMI and therefore may be a candidate for novel therapeutics of heart diseases. |
| WOS关键词 | MOLECULAR NETWORKS ; DRUG DISCOVERY ; HEART-FAILURE ; PATHWAY ; DEATH ; CELLS |
| 资助项目 | National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09308-005] ; National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09102-122] ; National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX090304-002] ; National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09311-001] ; National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2009ZX09502-020] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000294689200016 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278406]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Xu, Lingling |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Shenyang Pharmaceut Univ, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Lingling,Deng, Yanping,Feng, Lixin,et al. Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network[J]. PLOS ONE,2011,6(9). |
| APA | Xu, Lingling.,Deng, Yanping.,Feng, Lixin.,Li, Defang.,Chen, Xiaoyan.,...&Guo, Dean.(2011).Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network.PLOS ONE,6(9). |
| MLA | Xu, Lingling,et al."Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network".PLOS ONE 6.9(2011). |
入库方式： OAI收割
来源：上海药物研究所
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