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Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard

文献类型：期刊论文

作者Hou, Jin-Jun1,2; Wu, Wan-Ying1; Da, Juan1; Yao, Shuai1; Long, Hua-Li1; Yang, Zhou1; Cai, Lu-Ying1; Yang, Min1; Liu, Xuan1; Jiang, Bao-Hong1
刊名JOURNAL OF CHROMATOGRAPHY A
出版日期2011-08-19
卷号1218期号:33页码:5618-5627
关键词Robustness Conversion factor Salvia miltiorrhiza Botanical Single standard to determine multi-components (SSDMC) HPLC
ISSN号0021-9673
DOI10.1016/j.chroma.2011.06.058
文献子类Article
英文摘要Single standard to determine multi-components (SSDMC) is a novel and rational method for quality control of botanical products and traditional Chinese medicines (TCMs). However, it is restricted to wide application due to unknown fluctuation in conversion factors when it is performed in different laboratories. To evaluate the fluctuations of conversion factors, we selected Salvia miltiorrhiza as an example to determine three components of tanshinones by SSDMC method. Then ruggedness and robustness test were adopted to comprehensively investigate three kinds of factors that may influence stability of conversion factors, which were related with environmental parametric variables, operational parametric variables and peak measurement parametric variables. Nested-factorial-design was used to perform ruggedness tests. One-variable-at-a-time (OVAT) procedure and Plackett-Burman (PB) design were both used in robustness test. The results showed that stability of conversion factors was principally related with accuracy of wavelength of UV detector, peak measurement parameters and concentration of standard solution. The acceptable range of conversion factors was obtained from robustness test. Our results showed that conversion factors were inevitable to change, but when key parameters were well controlled, the range of its fluctuation was acceptable and the SSDMC method could be used widely in different laboratories. (C) 2011 Elsevier B.V. All rights reserved.
WOS关键词SALVIA-MILTIORRHIZA ; TANSHINONE-IIA ; HPLC ; CRYPTOTANSHINONE ; VALIDATION ; QUALITY
资助项目USP[00000000] ; ChP[00000000] ; National S&T Major Special Project for Major New Drugs Innovation[2009ZX09308-005] ; National S&T Major Special Project for Major New Drugs Innovation[2009ZX09102-122] ; National S&T Major Special Project for Major New Drugs Innovation[2009ZX090304-002] ; National S&T Major Special Project for Major New Drugs Innovation[2009ZX09311-001] ; National S&T Major Special Project for Major New Drugs Innovation[2009ZX09502-020] ; The Ministry of Science and Technology of the People's Republic of China[2006DFB31860]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000294031700008
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/278433]  
专题上海中药现代化研究中心
通讯作者Wu, Wan-Ying
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Hou, Jin-Jun,Wu, Wan-Ying,Da, Juan,et al. Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard[J]. JOURNAL OF CHROMATOGRAPHY A,2011,1218(33):5618-5627.
APA Hou, Jin-Jun.,Wu, Wan-Ying.,Da, Juan.,Yao, Shuai.,Long, Hua-Li.,...&Guo, De-An.(2011).Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard.JOURNAL OF CHROMATOGRAPHY A,1218(33),5618-5627.
MLA Hou, Jin-Jun,et al."Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard".JOURNAL OF CHROMATOGRAPHY A 1218.33(2011):5618-5627.

入库方式： OAI收割

来源：上海药物研究所

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