A facile and efficient method for the synthesis of solasodine from diosgenin
文献类型：期刊论文
| 作者 | Zhang, Gui-Ping1; Shen, Si-Da2; Lei, Min1 ; Hu, Li-Hong1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2011-08-19 |
| 卷号 | 67期号:33页码:5894-5896 |
| 关键词 | Steroidal spiroketal Solasodine Diosgenin TFAT |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2011.06.058 |
| 文献子类 | Article |
| 英文摘要 | A facile and high-yielding route for the synthesis of solasodine from diosgenin is devised. Ring opening of steroidal spiroketal under mild conditions with trifluoroacetyl trifluoromethanesulfonate (TFAT) provides an applicable protocol to prepare key intermediates 4 or 3-Ac-solasodine, which can potentially serve as a platform for the selective functionalization of C(3)-OH and N-H of solasodine. The simple operations without purification by column chromatography make this method suitable to scale up. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | GLYCOSIDES ; INHIBITION ; ALKALOIDS |
| 资助项目 | Chinese National Science and Technology Major Project[2009ZX09301-001] ; Chinese National Science and Technology Major Project[2009ZX09102-022] ; National Natural Science Foundation of China[21002027] ; National Natural Science Foundation of China[90713046] ; National Natural Science Foundation of China[30925040] ; CAS Foundation[KSCX2-YW-R-179] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000293606200005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278435]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Li-Hong |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Gui-Ping,Shen, Si-Da,Lei, Min,et al. A facile and efficient method for the synthesis of solasodine from diosgenin[J]. TETRAHEDRON,2011,67(33):5894-5896. |
| APA | Zhang, Gui-Ping,Shen, Si-Da,Lei, Min,&Hu, Li-Hong.(2011).A facile and efficient method for the synthesis of solasodine from diosgenin.TETRAHEDRON,67(33),5894-5896. |
| MLA | Zhang, Gui-Ping,et al."A facile and efficient method for the synthesis of solasodine from diosgenin".TETRAHEDRON 67.33(2011):5894-5896. |
入库方式： OAI收割
来源：上海药物研究所
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