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Structure elucidation of in vivo and in vitro metabolites of mangiferin

文献类型：期刊论文

作者Liu, Huihui1; Wang, Ke2; Tang, Yihong3; Sun, Zhaolin1; Jian, Longhai2; Li, Zhixiong1; Wu, Bin1; Huang, Chenggang1
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2011-07-15
卷号55期号:5页码:1075-1082
关键词Structure elucidation Mangiferin LC-ESI-MSn Metabolites Norathyriol
ISSN号0731-7085
DOI10.1016/j.jpba.2011.03.012
文献子类Article
英文摘要The in vivo and in vitro metabolism of mangiferin was systematically investigated. Urine, plasma, feces, contents of intestinal tract and various organs were collected after oral administration of mangiferin to healthy rats at a dose of 200 mg/kg body weight. For comparison, mangiferin was also incubated in vitro with intestinal flora of rats. With the aid of a specific and sensitive liquid chromatography coupled with electrospray ionization tandem hybrid ion trap mass spectrometry (LC-ESI-IT-MSn), a total of thirty-three metabolites of mangiferin were detected and their structures were tentatively elucidated on the basis of the characteristics of their precursor ions, product ions and chromatographic retention times. The biotransformation pathways of mangiferin involved deglycosylation, dehydroxylation, methylation, glycosylation, glucuronidation and sulfation. (C) 2011 Elsevier B.V. All rights reserved.
WOS关键词NATURALLY-OCCURRING GLUCOSYLXANTHONE ; GENISTOIDES HONEYBUSH TEA ; TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; ORAL INGESTION ; RAT URINE ; IDENTIFICATION ; XANTHONES ; DECOCTION ; GLUCOSIDE
资助项目National Science & Technology Major Project[2009ZX09301-001] ; National Science & Technology Major Project[2009ZX09301-005] ; National Natural Science Foundation of China[81030065] ; National Natural Science Foundation of China[20805054]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000291129700026
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/278474]  
专题上海中药现代化研究中心
通讯作者Huang, Chenggang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Shanghai Inst Food & Drug Control, Shanghai 201203, Peoples R China;
3.Shanghai Inst Technol, Shanghai 201418, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Huihui,Wang, Ke,Tang, Yihong,et al. Structure elucidation of in vivo and in vitro metabolites of mangiferin[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,55(5):1075-1082.
APA Liu, Huihui.,Wang, Ke.,Tang, Yihong.,Sun, Zhaolin.,Jian, Longhai.,...&Huang, Chenggang.(2011).Structure elucidation of in vivo and in vitro metabolites of mangiferin.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,55(5),1075-1082.
MLA Liu, Huihui,et al."Structure elucidation of in vivo and in vitro metabolites of mangiferin".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 55.5(2011):1075-1082.

入库方式： OAI收割

来源：上海药物研究所

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