An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-gamma-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene
文献类型：期刊论文
| 作者 | Liu, Peng1; Lei, Min1 ; Ma, Lei1; Hu, Lihong1,2
|
| 刊名 | SYNLETT
 |
| 出版日期 | 2011-05 |
| 期号 | 8页码:1133-1136 |
| 关键词 | N-heterocyclic carbenes (NHCs) umpolung cascade reaction Stetter reaction 2-aminofuran |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-0030-1259945 |
| 文献子类 | Article |
| 英文摘要 | An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter-gamma-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions. |
| WOS关键词 | ACTIVATED DOUBLE-BONDS ; ALPHA,BETA-UNSATURATED ALDEHYDES ; NUCLEOPHILIC CARBENE ; CONJUGATE UMPOLUNG ; BENZOIN REACTIONS ; DOMINO REACTIONS ; BUTYROLACTONES ; CONDENSATION ; ACYLOIN ; DERIVATIVES |
| 资助项目 | Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2009ZX09301-001] ; Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2009ZX09102-022] ; National Natural Science Foundation of China[21002027] ; National Natural Science Foundation of China[90713046] ; National Natural Science Foundation of China[30772638] ; National Natural Science Foundation of China[30925040] ; CAS Foundation[KSCX2-YW-R-179] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000290206600017 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278547]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ma, Lei |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 2.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Peng,Lei, Min,Ma, Lei,et al. An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-gamma-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene[J]. SYNLETT,2011(8):1133-1136. |
| APA | Liu, Peng,Lei, Min,Ma, Lei,&Hu, Lihong.(2011).An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-gamma-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene.SYNLETT(8),1133-1136. |
| MLA | Liu, Peng,et al."An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-gamma-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene".SYNLETT .8(2011):1133-1136. |
入库方式： OAI收割
来源：上海药物研究所
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