Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata
文献类型：期刊论文
| 作者 | Zhang, Xing3,4; Ye, Min3; Dong, Yin-Hui5; Hu, Hong-Bo5; Tao, Si-Jia2; Chen, Guang-Tong1; Yin, Jun4; Guo, De-An2,3
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| 刊名 | BIOCATALYSIS AND BIOTRANSFORMATION
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| 出版日期 | 2011-03 |
| 卷号 | 29期号:2-3页码:96-101 |
| 关键词 | Arenobufagin cinobufotalin biotransformation Alternaria alternata isomerization |
| ISSN号 | 1024-2422 |
| DOI | 10.3109/10242422.2011.578248 |
| 文献子类 | Article |
| 英文摘要 | The biotransformation of arenobufagin (1) and cinobufotalin (2), isolated from the natural medicine Chan Su, by Alternaria alternata AS 3.4578 was carried out. Incubation of 1 and 2 afforded six metabolites: 3-oxo-arenobufagin (1a), psi-bufarenogin (1b), 3-oxo-psi-bufarenogin (1c), 3-oxo-Delta(4)-derivative of cinobufotalin (2a), 3-oxo-cinobufotalin (2b) and 12 beta-hydroxycinobufotalin (2c). Among them, metabolites 1a, 1c and 2c are new compounds and their structures were characterized on the basis of their spectroscopic data (NMR, MS and IR). Compounds 1, 2, 1b, 2a and 2b were evaluated for their cytotoxicity against HepG2 and MCF-7 human cancer cells, and all of them showed significant inhibitory activities. |
| WOS关键词 | CYTOTOXIC BUFADIENOLIDES ; MICROBIAL TRANSFORMATION ; CATHARANTHUS-ROSEUS ; CINOBUFAGIN ; CHROMATOGRAPHY ; HYDROXYLATION ; PURIFICATION ; BUFALIN ; NMR |
| 资助项目 | Beijing NOVA Program[2009B02] ; Research Fund for Doctoral Program of Higher Education in China[00000000] ; National Science & Technology Major Project of China[2009ZX09304-002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000290868200008 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278587]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ye, Min |
| 作者单位 | 1.Med Sch Nantong Univ, Nantong, Peoples R China 2.Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai, Peoples R China; 3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China; 5.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100094, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xing,Ye, Min,Dong, Yin-Hui,et al. Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2011,29(2-3):96-101. |
| APA | Zhang, Xing.,Ye, Min.,Dong, Yin-Hui.,Hu, Hong-Bo.,Tao, Si-Jia.,...&Guo, De-An.(2011).Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata.BIOCATALYSIS AND BIOTRANSFORMATION,29(2-3),96-101. |
| MLA | Zhang, Xing,et al."Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata".BIOCATALYSIS AND BIOTRANSFORMATION 29.2-3(2011):96-101. |
入库方式： OAI收割
来源：上海药物研究所
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