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Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways

文献类型：期刊论文

作者Sun, Lijuan2,3; Liu, Jianwen2,3; Liu, Ping1; Yu, Youjun2,3; Ma, Lei2,3; Hu, Lihong4
刊名PROCESS BIOCHEMISTRY
出版日期2011-02
卷号46期号:2页码:482-488
关键词Physalis angulata L. Solanaceae Withangulatin A Immunosuppression HO-1 MAPK NF-kappa B
ISSN号1359-5113
DOI10.1016/j.procbio.2010.09.022
文献子类Article
英文摘要Withangulatin A (WA), a bioactive withanolide isolated from Physalis angulata L, has a strong immunosuppressive activity. We have demonstrated that WA significantly suppressed the over-proliferation of ConA-induced T lymphocytes in a dose- and time-dependent manner, which modulated Th1/Th2-type balance dramatically. Moreover, WA-induced heme oxygenase 1 (HO-1) expression in mice T lymphocytes through the ERK/MAPK pathway and inhibited ConA-induced nuclear factor kappa B (NF-kappa B p65) nuclear translocation, directly or indirectly mediated by HO-1. Notably, WA affected the expression of COX-2 and PPAR-gamma in ConA-induced T lymphocytes. The synergistic manner in which WA enhanced HO-1 expression through the ERK/MAPK pathway and NF-kappa B nuclear translocation and other regulatory proteins, thereby restricting T lymphocytes from over-expression and modulating Th1/Th2-type balance, could be the mechanism for the immunosuppressive properties of WA, the immunosuppressive effect of which may protect against autoimmune disorder diseases. (C) 2010 Elsevier Ltd. All rights reserved.
WOS关键词BRAIN TUMOR-CELLS ; CD4(+) T-CELLS ; NF-KAPPA-B ; WITHAFERIN-A ; EXPRESSION ; PROTEIN ; INDUCTION ; VIMENTIN ; RATS ; WITHANOLIDE
资助项目Ministry of Education of China[B07023] ; Shanghai Leading Academic Discipline Project[B507]
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering
语种英语
WOS记录号WOS:000287274000008
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/278612]  
专题上海中药现代化研究中心
通讯作者Liu, Jianwen
作者单位1.Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai 200032, Peoples R China;
2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;
3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;
4.Chinese Acad Sci, Shanghai Innovat Res Ctr Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Lijuan,Liu, Jianwen,Liu, Ping,et al. Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways[J]. PROCESS BIOCHEMISTRY,2011,46(2):482-488.
APA Sun, Lijuan,Liu, Jianwen,Liu, Ping,Yu, Youjun,Ma, Lei,&Hu, Lihong.(2011).Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways.PROCESS BIOCHEMISTRY,46(2),482-488.
MLA Sun, Lijuan,et al."Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways".PROCESS BIOCHEMISTRY 46.2(2011):482-488.

入库方式： OAI收割

来源：上海药物研究所

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