Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Ye, Guan; Tang, Yi-Hong; Xia, Guang-Xin; Sun, Zhao-Lin; Li, Zhi-Xiong ; Huang, Cheng-Gang
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
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| 出版日期 | 2010-11 |
| 卷号 | 24期号:11页码:1147-1151 |
| 关键词 | Radix Astragali Coxsackie virus B3 drug screening isoflavonoid saponin HPLC-DAD-MSn |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.1400 |
| 文献子类 | Article |
| 英文摘要 | To profile the anti-Coxsackie virus B3 constituents of Radix Astragali, an HPLC-DAD-MSn analytical method, combined with an in vivo test, has been developed to identify the constituents of the active part, which has been demonstrated to have potency to inhibit the proliferation of virus in cardiac muscle, alleviate infraction in heart and elevate the survival rate of the animal By comparing their retention time and MS data with those obtained from the authentic compounds and the published data, a total of 19 compounds, including 11 isoflavonoids and eight saponins, were identified, among which one pterocarpane glucoside was reported for the first time The present study provides an approach to rapidly screening bioactive constituents in traditional Chinese medicines Copyright (C) 2010 John Wiley & Sons, Ltd |
| WOS关键词 | ISOFLAVONOIDS ; ARRAY ; EXTRACTION ; PRODUCTS ; ROOTS |
| 资助项目 | National Science & Technology Marjor Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Natural Science Foundation of China[30500655] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000283761400001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278730]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng-Gang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guan,Tang, Yi-Hong,Xia, Guang-Xin,et al. Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2010,24(11):1147-1151. |
| APA | Ye, Guan,Tang, Yi-Hong,Xia, Guang-Xin,Sun, Zhao-Lin,Li, Zhi-Xiong,&Huang, Cheng-Gang.(2010).Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,24(11),1147-1151. |
| MLA | Ye, Guan,et al."Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 24.11(2010):1147-1151. |
入库方式： OAI收割
来源：上海药物研究所
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