Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii
文献类型：期刊论文
| 作者 | Zeng, Feng1,2; Wang, Wei3; Wu, Yunshan4; Dey, Moul1; Ye, Min2; Avery, Mitchell A.4; Khan, Ikhlas A.3; Guo, De-an2,5
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2010-10 |
| 卷号 | 76期号:14页码:1596-1599 |
| 关键词 | Celastraceae Tripterygium wilfordii anti-inflammatory antiproliferation flavonoid C-methylflavone |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0029-1241017 |
| 文献子类 | Article |
| 英文摘要 | Two unusual prenylated and C-methylated flavanones, (+/-)-5,4'-dihydroxy-2'-methoxy-6', 6 '''-dimethypyrano-(2 '', 3 '': 7,8)-6-methyflavanone (1) and (2S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone (2), and 10 known compounds were isolated from the stems and roots of Tripterygium wilfordii. Their structures were elucidated based on spectroscopic analyses including 1- and 2-D NMR, HR-ESI-MS, CD, and x-ray crystallography. The anti-inflammatory, antiproliferative, and antibacterial activities of compounds 1 and 2 were investigated. Compound 2 had an inhibitory effect on lipopolysaccharides (LPS)-triggered RAW cell nitric oxide (NO) production, with an IC(50) value of 15.0 +/- 0.7 mu M. Both compounds showed moderate antiproliferative activity against the tumor cell lines HT-29 and ZR-75-1. |
| WOS关键词 | HOOK-F ; FLAVANONES ; CHEMISTRY ; CANCER ; ROOTS ; CELLS ; WAXES ; ACID |
| 资助项目 | Changjiang Scholars and Innovation Team in University[985-2-063-112] ; Ministry of Education of China[104218] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000282366800019 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278767]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Rutgers State Univ, Biotech Ctr, New Brunswick, NJ 08903 USA; 2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China; 3.Univ Mississippi, Pharmaceut Sci Res Inst, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, University, MS 38677 USA; 4.Univ Mississippi, Dept Med Chem, University, MS 38677 USA; 5.CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Feng,Wang, Wei,Wu, Yunshan,et al. Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii[J]. PLANTA MEDICA,2010,76(14):1596-1599. |
| APA | Zeng, Feng.,Wang, Wei.,Wu, Yunshan.,Dey, Moul.,Ye, Min.,...&Guo, De-an.(2010).Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii.PLANTA MEDICA,76(14),1596-1599. |
| MLA | Zeng, Feng,et al."Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii".PLANTA MEDICA 76.14(2010):1596-1599. |
入库方式： OAI收割
来源：上海药物研究所
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