An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction
文献类型：期刊论文
| 作者 | Lei, Min1 ; Ma, Lei1; Hu, Lihong2
|
| 刊名 | MONATSHEFTE FUR CHEMIE
 |
| 出版日期 | 2010-09 |
| 卷号 | 141期号:9页码:1005-1008 |
| 关键词 | Multicomponent reactions Aldehyde Organocatalyst Green chemistry |
| ISSN号 | 0026-9247 |
| DOI | 10.1007/s00706-010-0357-6 |
| 文献子类 | Article |
| 英文摘要 | A Biginelli-type three-component reaction involving cyclopentanone, aromatic aldehyde, and urea or thiourea for preparation of pyrimidinone derivatives under neat conditions is described. This condensation reaction can also take place smoothly in the presence of vitamin B(1) in EtOH at 80 A degrees C in good yield. The procedure is simple, high-yielding, time-saving, and environment friendly. |
| WOS关键词 | ONE-POT SYNTHESIS ; SOLVENT-FREE CONDITIONS ; MULTICOMPONENT REACTIONS ; CHLORIDE ; DIHYDROPYRIMIDINONES ; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES ; ALDEHYDES ; NAPHTHOLS ; CATALYST ; WATER |
| 资助项目 | Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program''[2009ZX09301-001] ; Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program''[2009ZX09102] ; Chinese National High-tech RD Program[2007AA02Z147] ; National Natural Science Foundation of China[90713046] ; National Natural Science Foundation of China[30772638] ; National Natural Science Foundation of China[30925040] ; CAS Foundation[KSCX2-YW-R-179] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000281106200011 |
| 出版者 | SPRINGER WIEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278790]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ma, Lei |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Min,Ma, Lei,Hu, Lihong. An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction[J]. MONATSHEFTE FUR CHEMIE,2010,141(9):1005-1008. |
| APA | Lei, Min,Ma, Lei,&Hu, Lihong.(2010).An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction.MONATSHEFTE FUR CHEMIE,141(9),1005-1008. |
| MLA | Lei, Min,et al."An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction".MONATSHEFTE FUR CHEMIE 141.9(2010):1005-1008. |
入库方式： OAI收割
来源：上海药物研究所
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