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Microtubule-Binding Natural Products for Cancer Therapy

文献类型：期刊论文

作者Yue, Qing-Xi; Liu, Xuan1,2; Guo, De-An
刊名PLANTA MEDICA
出版日期2010-08
卷号76期号:11页码:1037-1043
关键词natural product microtubule-binding agent cancer antiangiogenisis drug resistance marine sources
ISSN号0032-0943
DOI10.1055/s-0030-1250073
文献子类Review
英文摘要Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer therapy. The present review summarizes the development of representative microtubule-binding natural products including agents binding to the colchicine-binding site, the Vinca alkaloid-binding site, the taxane-binding site and other binding sites. Future directions for the development of new anticancer microtubule-binding natural products are discussed. Finding new formulations, new targets and new sources of microtubule-binding natural products may enable more members of this kind of agent to be introduced into the clinic for cancer therapy.
WOS关键词COMBRETASTATIN A-4 PHOSPHATE ; VASCULAR DISRUPTING AGENTS ; TUMOR BLOOD-VESSELS ; STABILIZING AGENTS ; ANTICANCER DRUGS ; BREAST-CANCER ; BETA-TUBULIN ; CLINICAL DEVELOPMENT ; TARGETING AGENTS ; P-GLYCOPROTEIN
资助项目National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09102-122] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09308-005] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09311-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09502-020]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000280370900002
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/278824]  
专题上海中药现代化研究中心
通讯作者Liu, Xuan
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Coll Chinese Mat Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Yue, Qing-Xi,Liu, Xuan,Guo, De-An. Microtubule-Binding Natural Products for Cancer Therapy[J]. PLANTA MEDICA,2010,76(11):1037-1043.
APA Yue, Qing-Xi,Liu, Xuan,&Guo, De-An.(2010).Microtubule-Binding Natural Products for Cancer Therapy.PLANTA MEDICA,76(11),1037-1043.
MLA Yue, Qing-Xi,et al."Microtubule-Binding Natural Products for Cancer Therapy".PLANTA MEDICA 76.11(2010):1037-1043.

入库方式： OAI收割

来源：上海药物研究所

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