Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum
文献类型：期刊论文
| 作者 | Lin, Hong-Wei1; Sun, Ming-Xue1; Wang, Yun-Hua2; Yang, Liu-Meng2; Yang, Ying-Ruo2; Huang, Ning2; Xuan, Li-Jiang3 ; Xu, Ya-Ming3; Bai, Dong-Lu3; Zheng, Yong-Tang2
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2010-06 |
| 卷号 | 76期号:9页码:889-892 |
| 关键词 | Polygonum cuspidatum Polygonum multiflorum Polygonaceae chemical components anti-HIV-1 activity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0029-1240796 |
| 文献子类 | Article |
| 英文摘要 | The 70% EtOH extract of Polygonum cuspidatum showed inhibitory action against HIV-1-induced syncytium formation at non-cytotoxic concentrations in vitro with a 50% effective concentration (EC50) of 13.94 +/- 3.41 mu g/mL. Through bioactivity-guided fractionation, 20 phenolic compounds, including eight stilbenoids, were isolated from the roots of Polygonum cuspidatum, and their anti-HIV-1 activities were evaluated. Results showed that compounds 1, 13, 14, and 16 demonstrated fairly strong antiviral activity against HIV-1-induced cytopathic effects in C8166 lymphocytes at non-cytotoxic concentrations, with EC50 values of 4.37 +/- 1.96 mu g/mL, 19.97 +/- 5.09, 14.4 +/- 1.34 mu g/mL, and 11.29 +/- 6.26 mu g/mL and therapeutic index (TI) values of 8.12, > 10.02, > 13.89, and > 17.71, respectively. Other compounds showed either weak or no effects. Compound 6 also showed weak inhibition (153.42 +/- 19.25 mu g/mL); however, it possesses very good water solubility and showed almost no cytotoxicity (> 2000 mu g/mL), therefore achieving a fairly good TI (13.04). The activities of the two compounds (3 and 18) from Polygonum multiflorum were also assayed. The relationship between molecular structures and their bioactivities was also discussed. |
| WOS关键词 | STILBENE GLYCOSIDES ; CONSTITUENTS ; INHIBITORS ; CELLS |
| 资助项目 | National Natural Science Foundation of China[20872179] ; National Natural Science Foundation of China[30472141] ; Science and Technology Commission of Shanghai Municipality (STCSM)[08DZ1971504] ; Scientific and Technological Projects of China[2009ZX09501-029] ; Scientific and Technological Projects of China[2008ZX10005-005] ; 973 Program[2009CB522306] ; CAS[KSCX1-YW-R-24] ; CAS[KSCX2-YW-R-185] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000279668400008 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278893]  |
| 专题 | 上海中药现代化研究中心 院士及顾问专家 |
| 通讯作者 | Zheng, Yong-Tang |
| 作者单位 | 1.Second Mil Med Univ, Lab Toxicol & Pharmacol, Fac Naval Med, Shanghai, Peoples R China; 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Hong-Wei,Sun, Ming-Xue,Wang, Yun-Hua,et al. Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum[J]. PLANTA MEDICA,2010,76(9):889-892. |
| APA | Lin, Hong-Wei.,Sun, Ming-Xue.,Wang, Yun-Hua.,Yang, Liu-Meng.,Yang, Ying-Ruo.,...&Xiao, Kai.(2010).Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum.PLANTA MEDICA,76(9),889-892. |
| MLA | Lin, Hong-Wei,et al."Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum".PLANTA MEDICA 76.9(2010):889-892. |
入库方式： OAI收割
来源：上海药物研究所
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