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Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography/tandem mass spectrometry

文献类型：期刊论文

作者Huang, Huilian1,2; Chen, Guangtong1; Lu, Zhiqiang1; Zhang, Jinqiang1; Guo, De-An1
刊名BIOMEDICAL CHROMATOGRAPHY
出版日期2010-04
卷号24期号:4页码:426-432
关键词oxyresveratrol metabolite LC-MS/MS SPE
ISSN号0269-3879
DOI10.1002/bmc.1309
文献子类Article
英文摘要Oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) is a major compound isolated from Smilax china, a Chinese herbal medicine. The rat urine and bile samples were pretreated by solid-phase extraction method after oral administration at a dose of 100 mg/kg of oxyresveratrol. Seven metabolites were identified by LC-MS/MS method with electrospray ionization in negative ion mode. The results indicated that main metabolites of oxyresveratrol were monoglucuronided and monosulfated oxyresveratrol. Based on the results, the metabolic pathway of oxyresveratrol in rat urine and bile was proposed. Copyright (C) 2009 John Wiley & Sons, Ltd.
WOS关键词MORUS-ALBA ; RESVERATROL ; MECHANISM
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000276169100013
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/278926]  
专题上海中药现代化研究中心
通讯作者Guo, De-An
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
2.Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Huilian,Chen, Guangtong,Lu, Zhiqiang,et al. Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography/tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2010,24(4):426-432.
APA Huang, Huilian,Chen, Guangtong,Lu, Zhiqiang,Zhang, Jinqiang,&Guo, De-An.(2010).Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography/tandem mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,24(4),426-432.
MLA Huang, Huilian,et al."Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography/tandem mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 24.4(2010):426-432.

入库方式： OAI收割

来源：上海药物研究所

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