Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo
文献类型：期刊论文
| 作者 | Jiang, Baohong2 ; Zhang, Lin2; Wang, Yingchun2; Li, Ming2; Wu, Wanying2; Guan, Shuhong2; Liu, Xuan2; Yang, Min2; Wang, Junchen1; Guo, De-an2
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| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2009-07 |
| 卷号 | 47期号:7页码:1538-1544 |
| 关键词 | Doxorubicin Tanshinone IIA sodium sulfonate Cardiomyopathy |
| ISSN号 | 0278-6915 |
| DOI | 10.1016/j.fct.2009.03.038 |
| 文献子类 | Article |
| 英文摘要 | Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone HA sodium sulfonate (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity. In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore. the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone. These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RAT CARDIAC-CELLS ; SALVIA-MILTIORRHIZA ; OXIDATIVE STRESS ; MICE ; CARDIOMYOPATHY ; HYPERTROPHY ; SUPPRESSION ; APOPTOSIS ; DAMAGE ; MODEL |
| 资助项目 | International Science and Technology Cooperation Project[2006DFB31860] ; Ministry of Science and Technology of China[2006BA108B03-03] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267739300021 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279198]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Jiang, Baohong |
| 作者单位 | 1.Tongji Univ, Dept Pathol, Dongfang Hosp, Shanghai 200120, Peoples R China 2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Baohong,Zhang, Lin,Wang, Yingchun,et al. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2009,47(7):1538-1544. |
| APA | Jiang, Baohong.,Zhang, Lin.,Wang, Yingchun.,Li, Ming.,Wu, Wanying.,...&Guo, De-an.(2009).Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,47(7),1538-1544. |
| MLA | Jiang, Baohong,et al."Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 47.7(2009):1538-1544. |
入库方式： OAI收割
来源：上海药物研究所
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