中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo

文献类型:期刊论文

作者Jiang, Baohong2; Zhang, Lin2; Wang, Yingchun2; Li, Ming2; Wu, Wanying2; Guan, Shuhong2; Liu, Xuan2; Yang, Min2; Wang, Junchen1; Guo, De-an2
刊名FOOD AND CHEMICAL TOXICOLOGY
出版日期2009-07
卷号47期号:7页码:1538-1544
关键词Doxorubicin Tanshinone IIA sodium sulfonate Cardiomyopathy
ISSN号0278-6915
DOI10.1016/j.fct.2009.03.038
文献子类Article
英文摘要Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone HA sodium sulfonate (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity. In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore. the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone. These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury. (C) 2009 Elsevier Ltd. All rights reserved.
WOS关键词RAT CARDIAC-CELLS ; SALVIA-MILTIORRHIZA ; OXIDATIVE STRESS ; MICE ; CARDIOMYOPATHY ; HYPERTROPHY ; SUPPRESSION ; APOPTOSIS ; DAMAGE ; MODEL
资助项目International Science and Technology Cooperation Project[2006DFB31860] ; Ministry of Science and Technology of China[2006BA108B03-03]
WOS研究方向Food Science & Technology ; Toxicology
语种英语
WOS记录号WOS:000267739300021
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279198]  
专题上海中药现代化研究中心
通讯作者Jiang, Baohong
作者单位1.Tongji Univ, Dept Pathol, Dongfang Hosp, Shanghai 200120, Peoples R China
2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714
Jiang, Baohong,Zhang, Lin,Wang, Yingchun,et al. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2009,47(7):1538-1544.
APA Jiang, Baohong.,Zhang, Lin.,Wang, Yingchun.,Li, Ming.,Wu, Wanying.,...&Guo, De-an.(2009).Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,47(7),1538-1544.
MLA Jiang, Baohong,et al."Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 47.7(2009):1538-1544.

入库方式: OAI收割

来源:上海药物研究所

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