Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry
文献类型：期刊论文
| 作者 | Yang, Min2; Sun, Jianghao1; Lu, Zhiqiang2; Chen, Guangtong2; Guan, Shuhong2 ; Liu, Xuan2; Jiang, Baohong2; Ye, Min1; Guo, De-An1,2
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| 刊名 | JOURNAL OF CHROMATOGRAPHY A
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| 出版日期 | 2009-03-13 |
| 卷号 | 1216期号:11页码:2045-2062 |
| 关键词 | Phytochemical analysis Traditional Chinese medicine HPLC-MS Tandem mass spectrometry Quality control |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2008.08.097 |
| 文献子类 | Review |
| 英文摘要 | Traditional Chinese medicine (TCM) is commonly considered to operate due to the synergistic effects of all the major and minor components in the medicines. Hence sensitive and comprehensive analytical techniques are needed to acquire a better understanding of the pharmacological basis of the herb and to enhance the product quality control. The present review mainly focuses on the phytochemical analysis of TCMs using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) are the two commonly used ion sources. Triple quadrupole, ion trip (IT), Fourier transform ion cyclotron resonance (FTICR) and time-of-flight (TOF) mass spectrometers are used as on-line analyzer. The relationship between structural features and fragmentation patterns should be investigated as thoroughly as possible and hence be applied in the on-line analysis to deduce the Structures of detected peaks. Characteristic fragmentation behaviors of the reference standards, as well as information regarding polarity obtained from retention time data, on-line UV spectra, data from the literature and bio-sources of the compounds allowed the identification of the phytochemical constituents in the crude extracts. Although a mass spectrometer is not a universal detector, high-performance liquid chromatography Coupled with Multistage mass spectrometry (HPLC-MSn) technique was still proved to be a rapid and sensitive method to analyze the majority of the many constituents in herbal medicines, particularly for the detection of those present in minor or trace amounts. The methods established using HPLC-MS techniques facilitate the convenient and rapid quality control of traditional medicines and their pharmaceutical preparations. However, the quantitative analysis is not the topic of this review. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS关键词 | PRESSURE CHEMICAL-IONIZATION ; DIODE-ARRAY DETECTION ; OF-FLIGHT MASS ; RAPID STRUCTURAL-CHARACTERIZATION ; DIESTER-DITERPENOID ALKALOIDS ; RADIX SALVIA-MILTIORRHIZAE ; ZINGIBER-OFFICINALE ROSC. ; DAD-ESI-MSN ; ELECTROSPRAY-IONIZATION ; PHENOLIC-COMPOUNDS |
| 资助项目 | ministry of Sciences and Technology of China[2006BAI08B03-03] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000264226500010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279290]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-An |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Min,Sun, Jianghao,Lu, Zhiqiang,et al. Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2045-2062. |
| APA | Yang, Min.,Sun, Jianghao.,Lu, Zhiqiang.,Chen, Guangtong.,Guan, Shuhong.,...&Guo, De-An.(2009).Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(11),2045-2062. |
| MLA | Yang, Min,et al."Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.11(2009):2045-2062. |
入库方式： OAI收割
来源：上海药物研究所
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