中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 上海中药现代化研究中心
In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-beta-D-glucopyranoside against Coxsackie Virus B3

文献类型：期刊论文

作者Zhu, Haiyan1,2; Zhang, Yuanyuan3; Ye, Guan1; Li, Zhixiong1; Zhou, Pei2; Huang, Chenggang1
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
出版日期2009-01
卷号32期号:1页码:68-73
关键词Astragalus membranaceus calycosin-7-O-beta-D-glucopyranoside coxsackie virus B3 viral myocarditis
ISSN号0918-6158
DOI10.1248/bpb.32.68
文献子类Article
英文摘要Calycosin-7-O-beta-D-glucopyranoside (CCGR) is the main isoflavonoid compound isolated from Astragalus membranaceus var. Mongholicu (B-GE.) HSIAO, a Chinese herb medicine traditionally used to treat viral myocarditis. In this study, its antiviral activities against coxsackie virus B3 (CVB3) causing myocarditis were investigated. In vitro assay showed that CCGR displayed a low cytotoxicity and effectively inhibited CVB3-mediated cytopathic effects on Vero cells with an IC50, value of 25 mu g/ml. In an acute myocarditis murine model, treatment with 24 mg/kg CCGR for 14 d significantly improved the survival rate of mice infected with CVB3, alleviated pathological damages of cardiac muscles in the myocarditis mice, reduced the virus titers in the heart, decreased heart indexes and improved left ventricular function. These results showed that CCGR exerted significant antiviral activities against CVB3 both in vitro and in vivo, and identified CCGR as one of active ingredients in Astragalus membranaceus for the treatment of viral myocarditis.
WOS关键词KILLER-CELL ACTIVITY ; VIRAL MYOCARDITIS ; DILATED CARDIOMYOPATHY ; INTERFERON-GAMMA ; MEMBRANACEUS ; ASTRAGALUS ; HPLC
资助项目National Natural Science Foundation of China[30500655] ; Science and Technology Commission of Shanghai Municipality[06DZ22906] ; Science and Technology Commission of Shanghai Municipality[02DZ19114]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000262069200012
出版者PHARMACEUTICAL SOC JAPAN
源URL[http://119.78.100.183/handle/2S10ELR8/279348]  
专题上海中药现代化研究中心
通讯作者Zhou, Pei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Fudan Univ, Sch Pharmaceut Sci, Dept Biosynthet Med Chem, Shanghai 200032, Peoples R China;
3.Fudan Univ, Sch Life Sci, Dept Microbiol & Microbial Engn, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Haiyan,Zhang, Yuanyuan,Ye, Guan,et al. In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-beta-D-glucopyranoside against Coxsackie Virus B3[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2009,32(1):68-73.
APA Zhu, Haiyan,Zhang, Yuanyuan,Ye, Guan,Li, Zhixiong,Zhou, Pei,&Huang, Chenggang.(2009).In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-beta-D-glucopyranoside against Coxsackie Virus B3.BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(1),68-73.
MLA Zhu, Haiyan,et al."In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-beta-D-glucopyranoside against Coxsackie Virus B3".BIOLOGICAL & PHARMACEUTICAL BULLETIN 32.1(2009):68-73.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。