Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile
文献类型：期刊论文
| 作者 | Sun, Jiang-Hao2; Yang, Min1; Ma, Xiao-Chi2; Kang, Jie2; Han, Jian2; Guo, De-An1,2
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:6页码:482-489 |
| 关键词 | biotransformation cryptotanshinone Cunninghamella elegans diterpenes Salvia miltiorrhiza |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020902877754 |
| 文献子类 | Article |
| 英文摘要 | Cryptotanshinone (1) is one of the major bioactive constituents in Salvia miltiorrhiza Bunge. Preparative-scale biotransformation of cryptotanshinone by Cunninghamella elegans (AS 3.2082) produced three new products, which were identified as (3R, 15R)-3-hydroxycryptotanshinone (2), (3S, 15R)-3-hydroxycryptotanshinone (3), and (4S, 15R)-18-hydroxycryptotanshinone (4), respectively. The structural elucidation was based primarily on 1D and 2D NMR and HR-ESI-MS analyses. The absolute configuration of these three products was confirmed by comparison of their circular dichroism spectra with those of the known compounds. These biotransformed metabolites were used as for the comparison of in vivo metabolites in rat bile sample after intravenous administration and they are identical to three of the minor hydroxylated metabolites in vivo, which suggested that microbial biotransformation model was a useful and feasible approach for the preparation of mammalian metabolites in trace. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHIC DETERMINATION ; IN-VITRO CYTOTOXICITY ; SALVIA-MILTIORRHIZA ; PENICILLIUM-JANTHINELLUM ; ACTIVE METABOLITE ; TANSHINONE IIA ; PLASMA ; ROOTS ; URINE |
| 资助项目 | Program for Changjiang Scholars and Innovative Team in University[985-2-063-112] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000268665700002 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279390]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-An |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Jiang-Hao,Yang, Min,Ma, Xiao-Chi,et al. Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(6):482-489. |
| APA | Sun, Jiang-Hao,Yang, Min,Ma, Xiao-Chi,Kang, Jie,Han, Jian,&Guo, De-An.(2009).Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(6),482-489. |
| MLA | Sun, Jiang-Hao,et al."Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.6(2009):482-489. |
入库方式： OAI收割
来源：上海药物研究所
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