Possible target-related proteins of salvianolic acids in rat platelets
文献类型：期刊论文
| 作者 | Yao, Yan1,2; Liu, Ai-Hua1; Wu, Wan-Ying1 ; Guan, Shu-Hong1; Jiang, Bao-Hong1; Yang, Min1; Bi, Kai-Shun2; Liu, Xuan1; Guo, De-An1
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| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2008-11-03 |
| 卷号 | 1期号:3页码:135-138 |
| 关键词 | Salvianolic acids Platelet 2-DE Proteomics |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2008.07.003 |
| 文献子类 | Article |
| 英文摘要 | Salvianolic acids (SAs) extracted from Salvia miltiorrhiza could inhibit ADP-induced aggregation of rat washed platelets. To elucidate the cellular mechanism of the inhibitive effect on platelet aggregation, a proteomic method was used to find the possible target-related proteins of SA in platelets. Treatment of 150 mu g/ml SA caused the regulation of platelet levels of 12 proteins, which play important roles in calcium homeostasis, antioxidant system and cytoskeleton structure. The proteomic result was also confirmed by Western blotting. (C) 2008 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | AGGREGATION |
| 资助项目 | Chinese Academy of Sciences[SIMM709QN-14] ; Ministry of Science and Technology of the People's Republic of China[2006DFB31860] ; Science and Technology Commission of Shanghai Municipality[064319052] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000263033900002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279437]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Yan,Liu, Ai-Hua,Wu, Wan-Ying,et al. Possible target-related proteins of salvianolic acids in rat platelets[J]. PHYTOCHEMISTRY LETTERS,2008,1(3):135-138. |
| APA | Yao, Yan.,Liu, Ai-Hua.,Wu, Wan-Ying.,Guan, Shu-Hong.,Jiang, Bao-Hong.,...&Guo, De-An.(2008).Possible target-related proteins of salvianolic acids in rat platelets.PHYTOCHEMISTRY LETTERS,1(3),135-138. |
| MLA | Yao, Yan,et al."Possible target-related proteins of salvianolic acids in rat platelets".PHYTOCHEMISTRY LETTERS 1.3(2008):135-138. |
入库方式： OAI收割
来源：上海药物研究所
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