Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS
文献类型：期刊论文
| 作者 | Guo, Xiaozhen1,2; Cheng, Mingcang1; Hu, Pei1; Shi, Zhangpeng1; Chen, Shuoji1; Liu, Huan1,2; Shi, Haoyun1,2; Xu, Zhou1; Tian, Xiaoting1,2; Huang, Chenggang1,2
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2018-11-21 |
| 卷号 | 66期号:46页码:12227-12235 |
| 关键词 | norathyriol pharmacokinetics bioavailability metabolism HPLC-MS/MS |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.8b03763 |
| 文献子类 | Article |
| 英文摘要 | Norathyriol, an aglycone of mangiferin, is a bioactive tetrahydroxyxanthone present in mangosteen and many medicinal plants. However, the biological fate of norathyriol in vivo remains unclear. In this study, the absorption and metabolism of norathyriol in rats were evaluated through HPLC-MS/MS. Results showed that norathyriol was well absorbed, as indicated by its absolute bioavailability of 30.4%. Besides, a total of 21 metabolites of norathyriol were identified in rats, including methylated, glucuronidated, sulfated and glycosylated conjugates, which suggested norathyriol underwent extensive phase II metabolism. Among those metabolites, 15 metabolites were also identified in hepatocytes incubated with norathyriol, indicating the presence of hepatic metabolism. Furthermore, glucuronide and sulfate conjugates, rather than their parent compound, were found to be the main forms existing in vivo after administration of norathyriol, as implicated by the great increase of exposure of norathyriol determined after hydrolysis with beta-glucuronidase and sulfatase. The information obtained from this study contributes to better understanding of the pharmacological mechanism of norathyriol. |
| WOS关键词 | CHEMICAL-CONSTITUENTS ; NATURAL-PRODUCTS ; IN-VITRO ; INHIBITION ; DERIVATIVES ; XANTHONES ; SYSTEM |
| 资助项目 | National Natural Science Foundation of China[81030065] ; National Natural Science Foundation for Young Scientists of China[81603280] ; Strategic Priority Scientific and Technological Project of Chinese Academy of Science[XDA12040203] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09731016-003] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09201001-001-008] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000451496600009 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279490]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Tian, Xiaoting; Huang, Chenggang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Xiaozhen,Cheng, Mingcang,Hu, Pei,et al. Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(46):12227-12235. |
| APA | Guo, Xiaozhen.,Cheng, Mingcang.,Hu, Pei.,Shi, Zhangpeng.,Chen, Shuoji.,...&Huang, Chenggang.(2018).Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(46),12227-12235. |
| MLA | Guo, Xiaozhen,et al."Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.46(2018):12227-12235. |
入库方式： OAI收割
来源：上海药物研究所
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