Implementation of a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenum bufonis as a Case Study
文献类型：期刊论文
| 作者 | Wei, Wenlong1,2; Wang, Xia2; Hou, Jinjun2 ; Yao, Changliang2; Feng, Zijin2; Zhang, Jianqing2; Han, Sumei2; Deng, Yanping2; Huang, Yong2; Wu, Wanying2
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| 刊名 | MOLECULES
 |
| 出版日期 | 2018-11 |
| 卷号 | 23期号:11 |
| ISSN号 | 1420-3049 |
| 关键词 | mass spectrometry fingerprint Venenum bufonis quality control chemometrics analysis |
| DOI | 10.3390/molecules23113020 |
| 文献子类 | Article |
| 英文摘要 | The mass spectrometry (MS) has been widely used for profiling chemical components of traditional Chinese medicine (TCM). However, there are few studies reporting quality control of TCM based on mass spectrometry fingerprint (MSF) due to its complicated operation and high cost. The aim of this study was to extend the application of MSF for quality evaluation of TCM. In this study, an MSF based on single quadrupole mass spectrometry method was established, and was successfully used for the quality control of Venenum bufonis (VB), a famous TCM which was used clinically for cancer treatment in China. The results showed that the superiority of MSF for more chemical information exposure and the finding of more potential chemical markers (eight versus four) compared with the traditional photo-diode array (a kind of ultra violet detector, PDA). Besides, the performance of MSF was also validated by similarity and principle component analysis (PCA) of MS data acquired on two other mass spectrometry (low-resolution, triple quadrupole, QQQ, and high-resolution, quadruple time-of-flight, Q-TOF), showing high consistency with QQQ and Q-TOF, but robustness with few parameters' settings. Based on our study, MSF could be widely applied for the quality control of TCM. |
| WOS关键词 | QUALITY CONSISTENCY ; CHROMATOGRAPHY ; GINSENOSIDES |
| 资助项目 | National Natural Science Foundation of China[81530095] ; National Natural Science Foundation of China[81673591] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020348] ; National Standardization of Traditional Chinese Medicine Project[ZYBZH-K-LN-01] ; Science and Technology Commission Foundation of Shanghai[15DZ0502800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000451641900292 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279504]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Wanying; Guo, Dean |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wenlong,Wang, Xia,Hou, Jinjun,et al. Implementation of a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenum bufonis as a Case Study[J]. MOLECULES,2018,23(11). |
| APA | Wei, Wenlong.,Wang, Xia.,Hou, Jinjun.,Yao, Changliang.,Feng, Zijin.,...&Guo, Dean.(2018).Implementation of a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenum bufonis as a Case Study.MOLECULES,23(11). |
| MLA | Wei, Wenlong,et al."Implementation of a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenum bufonis as a Case Study".MOLECULES 23.11(2018). |
入库方式： OAI收割
来源：上海药物研究所
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