Asymmetric Synthesis of the C15-C32 Fragment of Alotamide and Determination of the Relative Stereochemistry
文献类型：期刊论文
| 作者 | Shi, Hao-yun1,2; Xie, Yang1; Hu, Pei1; Guo, Zi-qiong1,2; Lu, Yi-hong1,2; Gao, Yu1; Huang, Cheng-gang1,2
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2018-11 |
| 卷号 | 16期号:11 |
| 关键词 | alotamide asymmetric synthesis relative structural determination |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md16110414 |
| 文献子类 | Article |
| 英文摘要 | Alotamide is a cyclic depsipetide isolated from a marine cyanobacterium and possesses a unique activation of calcium influx in murine cerebrocortical neurons (EC50 4.18 mu M). Due to its limited source, the three stereocenters (C19, C28, and C30) in its polyketide fragment remain undetermined. In this study, the first asymmetric synthesis of its polyketide fragment was achieved. Four relative possible diastereomers were constructed with a boron-mediated enantioselective aldol reaction and Julia-Kocienski olefination as the key steps. Comparison of C-13 NMR spectra revealed the relative structure of fragment C15-C32 of alotamide. |
| WOS关键词 | CYCLIC DEPSIPEPTIDE ; POTENT |
| 资助项目 | National Natural Science Foundation of China for Young Scientists[81602998] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09731016-003] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09201001-001-008] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000451159500017 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279507]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Gao, Yu; Huang, Cheng-gang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Hao-yun,Xie, Yang,Hu, Pei,et al. Asymmetric Synthesis of the C15-C32 Fragment of Alotamide and Determination of the Relative Stereochemistry[J]. MARINE DRUGS,2018,16(11). |
| APA | Shi, Hao-yun.,Xie, Yang.,Hu, Pei.,Guo, Zi-qiong.,Lu, Yi-hong.,...&Huang, Cheng-gang.(2018).Asymmetric Synthesis of the C15-C32 Fragment of Alotamide and Determination of the Relative Stereochemistry.MARINE DRUGS,16(11). |
| MLA | Shi, Hao-yun,et al."Asymmetric Synthesis of the C15-C32 Fragment of Alotamide and Determination of the Relative Stereochemistry".MARINE DRUGS 16.11(2018). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。