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Characterization and discrimination of steroidal saponins in Tribulus terrestris L. and its three different aerial parts by chemical profiling with chemometrics analysis

文献类型：期刊论文

作者Qi, Peng2; Zheng, Yuanyuan1,2; Shen, Yao2; Wang, Jianwei2; Bi, Qirui2; Feng, Ruihong2; Yang, Min2; Hou, Jinjun2; Wu, Wanying2; Sun, Shenguo3
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2018-11
卷号41期号:22
关键词partial least squares discriminant analysis steroidal saponins support vector machines traditional Chinese medicine Tribulus terrestris L
ISSN号1615-9306
DOI10.1002/jssc.201800513
文献子类Article
英文摘要Tribulus terrestris L. is a well-known medicinal plant from subtropical areas. In China Pharmacopoeia, only the fruit of T. terrestris is recorded to be the medicinal part. But some pharmaceutical preparations and food supplements made of total saponins of aerial part of T. terrestris including fruits, stems, and leaves are commercially available. However, steroidal saponins in different parts have not been studied extensively. So differentiating three parts and ensuring reasonable application of T. terrestris has been an important issue. Herein, we developed an integrated platform based on components profiling and chemometrics analysis to comparatively characterize and investigate steroidal saponins in three parts. As a result, a total of 84 steroidal saponins were characterized or tentatively identified, including 20 compounds reported for the first time. A clear separation of the three parts was achieved by partial least squares discriminant analysis based on the identified saponins, and 17 saponins were screened as biomarkers. Support vector machines model established based on 17 markers showed excellent predication accuracy of 100%. Finally, different distribution of steroidal saponins in three parts was shown obviously by heatmap visualization. These results provide promising perspectives for quality control of Chinese medicine, especially those with different medical parts.
WOS关键词PERFORMANCE LIQUID-CHROMATOGRAPHY ; FLIGHT MASS-SPECTROMETRY ; MS ; EXTRACTION ; FRUITS ; RATS
资助项目National Natural Science Foundation of China[81473344] ; National Natural Science Foundation of China[81530095] ; National Standardization of Traditional Chinese Medicine Project[ZYBZH-K-LN-01]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000450408300014
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/279510]  
专题上海中药现代化研究中心
通讯作者Hou, Jinjun; Wu, Wanying
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China;
2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China;
3.Jilin Aodong Taonan Pharmaceut Co Ltd, Jilin, Jilin, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Peng,Zheng, Yuanyuan,Shen, Yao,et al. Characterization and discrimination of steroidal saponins in Tribulus terrestris L. and its three different aerial parts by chemical profiling with chemometrics analysis[J]. JOURNAL OF SEPARATION SCIENCE,2018,41(22).
APA Qi, Peng.,Zheng, Yuanyuan.,Shen, Yao.,Wang, Jianwei.,Bi, Qirui.,...&Sun, Shenguo.(2018).Characterization and discrimination of steroidal saponins in Tribulus terrestris L. and its three different aerial parts by chemical profiling with chemometrics analysis.JOURNAL OF SEPARATION SCIENCE,41(22).
MLA Qi, Peng,et al."Characterization and discrimination of steroidal saponins in Tribulus terrestris L. and its three different aerial parts by chemical profiling with chemometrics analysis".JOURNAL OF SEPARATION SCIENCE 41.22(2018).

入库方式： OAI收割

来源：上海药物研究所

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