Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica
文献类型：期刊论文
| 作者 | Jin, Qinghao2,3; Lee, Jin Woo2; Jang, Hari2; Lee, Hye Lim2; Kim, Jun Gu2; Wu, Wanying3 ; Lee, Dongho4; Kim, Eun-Hee1; Kim, Youngsoo2; Hong, Jin Tae2
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2018-11 |
| 卷号 | 155页码:107-113 |
| 关键词 | Inula japonica Asteraceae Sesquiterpene trimer Sesquiterpenes dimer Cytotoxic activity Nitric oxide |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2018.07.008 |
| 文献子类 | Article |
| 英文摘要 | An undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3' and C-11'C-1" via a Diels-Alder cycloaddition reaction. Inulajaponicolides C and D exhibited moderate cytotoxic activity against A 549 and NCI-H460 human cancer cell lines with IC50 values ranging from 8.5 to 17.8 mu M. Inulajaponicolides A-D and lineariifolianoid A possessed significant inhibitory potency against nitric oxide production in LPS-induced RAW264.7 cells with IC50 values ranging from 1.0 to 4.1 M. |
| WOS关键词 | A-D ; CARPESIUM-FABERI ; LACTONE DIMERS ; CYTOTOXICITY ; THUNB ; CELLS |
| 资助项目 | Medical Research Center Program (MRC) through the National Research Foundation of Korea[2017R1A5A2015541] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000447483900013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279523]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hwan, Bang Yeon |
| 作者单位 | 1.Korea Basic Sci Inst, Prot Struct Grp, Ochang 28119, Chungbuk, South Korea 2.Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Korea Univ, Dept Biosyst & Biotechnol, Coll Life Sci & Biotechnol, Seoul 02841, South Korea; |
| 推荐引用方式 GB/T 7714 | Jin, Qinghao,Lee, Jin Woo,Jang, Hari,et al. Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica[J]. PHYTOCHEMISTRY,2018,155:107-113. |
| APA | Jin, Qinghao.,Lee, Jin Woo.,Jang, Hari.,Lee, Hye Lim.,Kim, Jun Gu.,...&Hwan, Bang Yeon.(2018).Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica.PHYTOCHEMISTRY,155,107-113. |
| MLA | Jin, Qinghao,et al."Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica".PHYTOCHEMISTRY 155(2018):107-113. |
入库方式： OAI收割
来源：上海药物研究所
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