Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells
文献类型：期刊论文
| 作者 | Zhang, Jianqing1,2; Jin, Qinghao1; Li, Shiyou3; Wu, Jia1; Wang, Zhen3 ; Hou, Jinjun1; Qu, Hua1; Long, Huali1; Wu, Wanying1; Guo, Dean1,2
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| 刊名 | NEW JOURNAL OF CHEMISTRY
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| 出版日期 | 2018-08-21 |
| 卷号 | 42期号:16页码:13414-13420 |
| ISSN号 | 1144-0546 |
| DOI | 10.1039/c8nj02027b |
| 文献子类 | Article |
| 英文摘要 | Two new sesquiterpenes (1-2) and three new nor-sesquiterpenes (3-5) were obtained from the rhizome of Alisma orientale (Sam.) Juzep, one of which (2) possessed an unprecedented cyclopentene and furanone containing natural skeleton. Their structures and relative stereochemistry were elucidated by NMR spectroscopy (H-1 and C-13 NMR, HSQC, HMBC, NOESY) and electronic circular dichroism (ECD) and HR-ESI-MS data analyses. Two plausible biosynthetic pathways for compound 1 and 2 were discussed. The nephrotoxicities of these compounds were evaluated on normal human HK2 cells by high content screening, and neither the MeOH extract nor the compounds possessed potential nephrotoxicity in vitro. |
| WOS关键词 | CONTENT SCREENING TECHNOLOGY ; DRUG-INDUCED HEPATOTOXICITY ; TRITERPENES ; 23-ACETATE ; AUTOPHAGY ; RATS |
| 资助项目 | Shanghai Municipal Science and Technology Commission[15DZ05022800] ; National Standardization Program for Chinese Medicine[ZYBZH-K-LN-01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000445827700019 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279613]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Wanying; Guo, Dean |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China; 3.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jianqing,Jin, Qinghao,Li, Shiyou,et al. Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells[J]. NEW JOURNAL OF CHEMISTRY,2018,42(16):13414-13420. |
| APA | Zhang, Jianqing.,Jin, Qinghao.,Li, Shiyou.,Wu, Jia.,Wang, Zhen.,...&Guo, Dean.(2018).Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells.NEW JOURNAL OF CHEMISTRY,42(16),13414-13420. |
| MLA | Zhang, Jianqing,et al."Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells".NEW JOURNAL OF CHEMISTRY 42.16(2018):13414-13420. |
入库方式： OAI收割
来源：上海药物研究所
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