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The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome

文献类型：期刊论文

作者Da, Juan2; Yang, Lin2; Wu, Wan-ying2; Guo, De-an2; Panossian, Alexander G.1,3
刊名PHYTOCHEMISTRY LETTERS
出版日期2018-02
卷号23页码:155-163
关键词1,4-Androstadiene-3,17-dione Rhodiola rosea Doping
ISSN号1874-3900
DOI10.1016/j.phytol.2017.12.007
文献子类Article
英文摘要Background: Rhodiola rosea L. roots and rhizome (RRR) extracts are used as dietary supplements for temporary relief of symptoms of stress, such as fatigue, sensation of weakness, and for improvement of mental and cognitive function. RRR containing products are also of interest to sports nutrition experts and antidoping authorities. It has been suggested that nutritional supplements containing Rhodiola rosea extracts be examined for the presence of (pseudo-) endogenous steroids, specifically for the presence of 1,4-androstadiene-3,17-dione (ADD) which can potentially lead to adverse analytical findings (AAFs) in doping controls. Aim of the study: The aim of the present study was to detect and quantify ADD in Rhodiola roots and rhizomes collected in various geographical locations of North America, Europe, and Asia. Results: ADD was not found in RRR by any of three methods used in this study. No peaks corresponding to ADD in chromatograms of RRR extract were detected at the limit of quantification corresponding to 1.6 ng/g of ADD in dry rhizomes of Rhodiola rosea. Conclusion: The anabolic steroid 1,4-androstadiene-3,17-dione was not detectable in the Rhodiola rosea roots and rhizomes, at least not present in amounts which may be a concern for athletes who want to avoid the consumption of this anabolic agent with Rhodiola dietary supplementation.
WOS关键词ADAPTOGENS ; EFFICACY ; ANDROSTENEDIONE ; PERFORMANCE ; SUPPLEMENTS ; BOLDENONE ; EXERCISE
资助项目Shanghai Research Center for TCM Modernization at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China[00000000] ; Swedish Herbal Institute Research and Development, Kovlingevagen, Vallberga, Sweden[00000000]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000426096600029
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/279923]  
专题上海中药现代化研究中心
通讯作者Guo, De-an; Panossian, Alexander G.
作者单位1.EuroPharmaUSA Inc, 955 Challenger Dr, Green Bay, WI 54311 USA
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Beijing, Peoples R China;
3.Swedish Herbal Inst Res & Dev, Kovlingevagen 21, S-31250 Vallberga, Sweden;
推荐引用方式
GB/T 7714		 Da, Juan,Yang, Lin,Wu, Wan-ying,et al. The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome[J]. PHYTOCHEMISTRY LETTERS,2018,23:155-163.
APA Da, Juan,Yang, Lin,Wu, Wan-ying,Guo, De-an,&Panossian, Alexander G..(2018).The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome.PHYTOCHEMISTRY LETTERS,23,155-163.
MLA Da, Juan,et al."The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome".PHYTOCHEMISTRY LETTERS 23(2018):155-163.

入库方式： OAI收割

来源：上海药物研究所

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