Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection
文献类型：期刊论文
| 作者 | Zhu, Haiyan1; Chen, Mingcang2; Shi, Xunlong1; Shi, Chenchen1; Huang, Chenggang2
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
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| 出版日期 | 2018-02 |
| 卷号 | 32期号:2 |
| 关键词 | antiviral research component analysis Influenza A virus LC/QTOF/MS Tanreqing Injection |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.4097 |
| 文献子类 | Article |
| 英文摘要 | Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated to have effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components. In the present study, a high-performance and practical LC/QTOF/MS method was developed for characterization and identification of the natural ingredients in TRQ. A total of 60 compounds, including 10 amino acids, 10 iridoid glucosides, 14 flavonoids, 13 other phenolic compounds, 10 steroid acids and three other compounds, were characterized and identified. We also confirmed the material basis of anti-Influenza A active ingredients in TRQ. Therefore, we have developed an accurate analytical method. LC/QTOF/MS could be applied for identification the complex components in traditional Chinese medicine. |
| WOS关键词 | A H1N1 VIRUS ; TRADITIONAL CHINESE MEDICINE ; FORSYTHIA-SUSPENSA FRUITS ; FLOS LONICERAE JAPONICAE ; FLIGHT MASS-SPECTROMETRY ; HEPATITIS-C VIRUS ; Q-TOF-MS ; CAFFEIC ACID ; CHENODEOXYCHOLIC ACID ; QUANTITATIVE-ANALYSIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000423404000046 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279939]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Zhu, Haiyan; Huang, Chenggang |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Microbiol & Biochem Pharm, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Haiyan,Chen, Mingcang,Shi, Xunlong,et al. Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection[J]. BIOMEDICAL CHROMATOGRAPHY,2018,32(2). |
| APA | Zhu, Haiyan,Chen, Mingcang,Shi, Xunlong,Shi, Chenchen,&Huang, Chenggang.(2018).Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection.BIOMEDICAL CHROMATOGRAPHY,32(2). |
| MLA | Zhu, Haiyan,et al."Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection".BIOMEDICAL CHROMATOGRAPHY 32.2(2018). |
入库方式： OAI收割
来源：上海药物研究所
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