热门
Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression
文献类型：期刊论文
| 作者 | Pu, Mengfan2; Chen, Jing2 ; Tao, Zhouteng2; Miao, Lingling2; Qi, Xinming2; Wang, Yizheng1; Ren, Jin2
|
| 刊名 | Cellular and molecular life sciences : CMLS
 |
| 出版日期 | 2018-10-29 |
| ISSN号 | 1420-9071 |
| DOI | 10.1007/s00018-018-2940-7 |
| 文献子类 | Article;Review |
| 英文摘要 | MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3' UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266245]  |
| 专题 | 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Ren, Jin |
| 作者单位 | 1.The Brain Science Center, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China 2.Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; |
| 推荐引用方式 GB/T 7714 | Pu, Mengfan,Chen, Jing,Tao, Zhouteng,et al. Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression[J]. Cellular and molecular life sciences : CMLS,2018. |
| APA | Pu, Mengfan.,Chen, Jing.,Tao, Zhouteng.,Miao, Lingling.,Qi, Xinming.,...&Ren, Jin.(2018).Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.Cellular and molecular life sciences : CMLS. |
| MLA | Pu, Mengfan,et al."Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression".Cellular and molecular life sciences : CMLS (2018). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。