Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation
文献类型：期刊论文
| 作者 | Luan, Yang3; Xing, Guozhen2; Ren, Jin2 ; Gu, Jun1
|
| 刊名 | Genes and environment : the official journal of the Japanese Environmental Mutagen Society
 |
| 出版日期 | 2015 |
| 卷号 | 37页码:11 |
| ISSN号 | 1880-7046 |
| DOI | 10.1186/s41021-015-0010-z |
| 文献子类 | Article |
| 英文摘要 | Hepatic cytochrome P450s (CYPs) play an important role in the metabolism of plant carcinogen, aristolochic acid I (AAI). In the present study, we employed hepatic NADPH-cytochrome P450 reductase null (HRN) gpt delta transgenic mice to investigate the role of hepatic CYPs in the metabolism of AAI. DNA adduct formation, gene mutation, and tumor induction in the liver and kidneys were analyzed. Pharmacokinetic analyses were performed and tissue levels of AAI were determined. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266330]  |
| 专题 | 药物安全性评价中心 |
| 作者单位 | 1.Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201-0509 USA 2.Center for Drug Safety and Evaluation Research, State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China; 3.Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025 China; |
| 推荐引用方式 GB/T 7714 | Luan, Yang,Xing, Guozhen,Ren, Jin,et al. Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation[J]. Genes and environment : the official journal of the Japanese Environmental Mutagen Society,2015,37:11. |
| APA | Luan, Yang,Xing, Guozhen,Ren, Jin,&Gu, Jun.(2015).Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society,37,11. |
| MLA | Luan, Yang,et al."Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation".Genes and environment : the official journal of the Japanese Environmental Mutagen Society 37(2015):11. |
入库方式： OAI收割
来源：上海药物研究所
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