MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy
文献类型：期刊论文
| 作者 | Tao, Zhouteng2; Feng, Chenxi2; Mao, Chenmei2; Ren, Jin3 ; Tai, Yusi3; Guo, Huijie3; Pu, Mei3; Zhou, Yang3; Wang, Guanghui1; Wang, Mei2
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| 刊名 | Cell stress & chaperones
 |
| 出版日期 | 2018-11-12 |
| ISSN号 | 1466-1268 |
| DOI | 10.1007/s12192-018-0946-6 |
| 文献子类 | Article |
| 英文摘要 | Autophagy plays an important role in maintaining cell function. Abnormal autophagy leads to cell dysfunction and is associated with many diseases such as tumors, immunodeficiency diseases, lysosomal storage disorders, and neurodegenerative diseases. Autophagy is precisely regulated, and PTEN plays an important role in regulating autophagy. As noncoding small RNAs, miRNAs play an important role in the fine regulation of cellular processes. However, the mechanism of the miRNA regulation of PTEN-related autophagy has not been fully elucidated. In this study, our results showed that miR-4465 significantly inhibited the expression of PTEN, upregulated phosphorylated AKT, and thereby inhibited autophagy by activating mTOR in HEK293, HeLa, and SH-SY5Y cells. Further studies indicated that miR-4465 reduced PTEN mRNA levels through posttranscriptional regulation via directly targeting the 3'-UTR. Our novel findings provide useful hints for the comprehensive elucidation of the molecular mechanism of miRNA-regulated PTEN-related autophagy and may also provide some new insights for the exploration of miRNAs in the treatment of PTEN-related diseases. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266815]  |
| 专题 | 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Wang, Mei |
| 作者单位 | 1.Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215021, China 2.Department of Pharmacy, Children's Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, China; 3.Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; |
| 推荐引用方式 GB/T 7714 | Tao, Zhouteng,Feng, Chenxi,Mao, Chenmei,et al. MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy[J]. Cell stress & chaperones,2018. |
| APA | Tao, Zhouteng.,Feng, Chenxi.,Mao, Chenmei.,Ren, Jin.,Tai, Yusi.,...&Wang, Mei.(2018).MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy.Cell stress & chaperones. |
| MLA | Tao, Zhouteng,et al."MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy".Cell stress & chaperones (2018). |
入库方式： OAI收割
来源：上海药物研究所
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