Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases
文献类型：期刊论文
| 作者 | Cai, Yingying2; Yang, Cuixia2; Yu, Xiaohan3; Qian, Jie4; Dai, Min4; Wang, Yan5,6; Qin, Chaoyan2; Lai, Weiming2; Chen, Shuai2; Wang, Tingting2 |
| 刊名 | Journal of immunology (Baltimore, Md. : 1950)
 |
| 出版日期 | 2018-12-12 |
| ISSN号 | 1550-6606 |
| DOI | 10.4049/jimmunol.1800261 |
| 文献子类 | Article |
| 英文摘要 | Altered migration and immune responses of dendritic cells (DCs) lead to inflammatory and autoimmune diseases. Our studies demonstrated that β-arrestin 2 deficiency promoted migration and cytokine production of mouse bone marrow-derived DCs. We further found that β-arrestin 2 directly interacted with Zbtb46, a DC-specific transcription factor. What's more, our results suggested that the interaction between β-arrestin 2 and Zbtb46 might negatively regulate DC migration. Using RNA sequencing, we indicated that genes CD74, NR4A1, and ZFP36 might be the target genes regulated by the interaction between β-arrestin 2 and Zbtb46. Mice with selective deficiency of β-arrestin 2 in DCs developed severer experimental autoimmune encephalomyelitis with more DC infiltration in the CNS and increased IL-6 in serum. In the systemic lupus erythematosus mice model, Arrb2 Itgax-cre mice were prone to exacerbation of lupus nephritis with a higher level of IL-6 and DC accumulation. Taken together, our study identified β-arrestin 2 as a new regulator of DC migration and immune properties, providing new insights into the mechanisms underlying the development of autoimmune disease. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266826]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Du, Changsheng |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 2.Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; 3.Department of Respiratory and Gastroenterology, Yingshan People's Hospital, Yingshan, Hubei 436700, China; 4.Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China; 5.Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200031, China; 6.and; |
| 推荐引用方式 GB/T 7714 | Cai, Yingying,Yang, Cuixia,Yu, Xiaohan,et al. Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases[J]. Journal of immunology (Baltimore, Md. : 1950),2018. |
| APA | Cai, Yingying.,Yang, Cuixia.,Yu, Xiaohan.,Qian, Jie.,Dai, Min.,...&Du, Changsheng.(2018).Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases.Journal of immunology (Baltimore, Md. : 1950). |
| MLA | Cai, Yingying,et al."Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases".Journal of immunology (Baltimore, Md. : 1950) (2018). |
入库方式： OAI收割
来源：上海药物研究所
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